Document Detail


Sex differences in the activational effects of gonadal hormones on food intake and body weight.
MedLine Citation:
PMID:  6522475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Estrogens have been shown to decrease, and androgens to increase body weight (BWt) of guinea pigs (GPs). The magnitude of the BWt sex difference shown by intact adult GPs is due primarily to these concurrent, or activational, effects of gonadal steroids. However, a small but significant sex difference in BWt persists in animals gonadectomized at birth, indicating that early hormonal exposure may permanently influence certain steroid sensitive weight regulatory mechanisms in the two sexes. Three experiments were therefore designed to investigate the short term effects of estradiol and testosterone on food intake (FI) and BWt of gonadectomized adult male and female GPs. In the first experiment, GPs gonadectomized in adulthood were given a single injection of 6 micrograms estradiol benzoate (EB). Although EB treatment reduced FI and BWt of both females and males, significantly larger reductions occurred in females. In the second experiment, GPs gonadectomized at birth received treatments of oil or 2 micrograms EB for 7 days. EB treatment also produced significantly larger effects on FI and BWt in the neonatally gonadectomized females. The third experiment involved GPs gonadectomized as adults who were injected with either oil or 1 mg/day testosterone propionate in oil (TP) for 32 days. Compared to changes in oil injected controls, TP produced significantly larger increases in male BWt than female BWt. Therefore, although GPs show only minor sex differences in BWt which might relate to prenatal gonadal hormonal exposure, significant sex differences remain in their responsiveness to the activational effects of gonadal steroids on FI and BWt in adulthood.
Authors:
J A Czaja
Related Documents :
1126455 - Influence of estrogen and progesterone treatment on ovarian contractility in the monkey.
11987895 - Oestrogens and puberty.
16645775 - Effects of an no synthase inhibitor on aggressive and sexual behavior in male crickets.
12590755 - A female melanin ornament signals offspring fluctuating asymmetry in the barn owl.
23507625 - Cloning and tissue distribution of a fatty acyl Δ6-desaturase-like gene and effects of ...
13129465 - A western-style diet reduces bone mass and biomechanical bone strength to a greater ext...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  33     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-03-18     Completed Date:  1985-03-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  553-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology
Body Weight / drug effects*
Castration
Estradiol / pharmacology*
Feeding Behavior / drug effects*
Female
Guinea Pigs
Male
Sex Characteristics*
Sexual Behavior, Animal / drug effects
Testosterone / pharmacology*
Grant Support
ID/Acronym/Agency:
NIMH 21312/MH/NIMH NIH HHS; RR00167/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sodium chloride intake following electrochemical stimulation of the frontal lobe cortex in the rat.
Next Document:  Perseveration of attention to conspecific odors and novel objects in castrated gerbils.