Document Detail


Sex difference and response to testosterone in gabaergic cells of the medial preoptic nucleus and ventral bed nuclei of the stria terminalis in gerbils.
MedLine Citation:
PMID:  21281643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The medial preoptic nucleus (MPN) and ventral bed nuclei of the stria terminalis (BST) are needed to maintain mating in sexually experienced male gerbils and rats. The gerbil ventral BST is also activated with mating, as assessed by Fos expression, as is the medial MPN (MPNm) of both species. In gerbils, many of those mating-activated cells contain glutamic acid decarboxylase (GAD), the enzyme that synthesizes γ-aminobutyric acid (GABA). Some of those cells are projection neurons, but others may release GABA locally. Through actions in the medial preoptic area, GABA inhibits and testosterone (T) promotes male sex behavior. Thus, T may promote mating, in part, by decreasing GAD in MPNm or ventral BST cells. In rats, T increases GAD mRNA in the central MPN (MPNc), where MPN GABAergic cells are densest, but mating behavior does not change in sexually experienced males when the MPNc is ablated. Therefore, this study focused on the MPNm and ventral BST to ask whether their GABAergic cells respond to T or are sexually dimorphic. This was done by visualizing cells immunoreactive (IR) for GAD(67), an isoform found primarily in cell bodies, in male and female gerbils and in castrated males with and without T. At both sites, males had more GAD(67)-IR cells than females, and T decreased GAD(67)-IR cell numbers in males. Thus, the MPNm and ventral BST have GABAergic cells that are sexually dimorphic and in which T decreases GAD, consistent with local effects of T and GABA on mating.
Authors:
Pauline Yahr
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-31
Journal Detail:
Title:  Hormones and behavior     Volume:  59     ISSN:  1095-6867     ISO Abbreviation:  Horm Behav     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-22     Completed Date:  2011-08-15     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurobiology and Behavior University of California, Irvine, CA 92697-4550, USA. piyahr@uci.edu
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MeSH Terms
Descriptor/Qualifier:
Androgens / metabolism,  pharmacology*
Animals
Female
Gerbillinae
Glutamate Decarboxylase / metabolism
Immunohistochemistry
Male
Neurons / drug effects*,  metabolism
Orchiectomy
Preoptic Area / drug effects*,  metabolism
Random Allocation
Septal Nuclei / drug effects*,  metabolism
Sex Characteristics*
Sex Factors
Testosterone / metabolism,  pharmacology*
gamma-Aminobutyric Acid / metabolism*
Grant Support
ID/Acronym/Agency:
MH-26481/MH/NIMH NIH HHS; R01 MH026481-24/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Androgens; 56-12-2/gamma-Aminobutyric Acid; 58-22-0/Testosterone; EC 4.1.1.15/Glutamate Decarboxylase; EC 4.1.1.15/glutamate decarboxylase 1
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