| Sex difference and response to testosterone in gabaergic cells of the medial preoptic nucleus and ventral bed nuclei of the stria terminalis in gerbils. | |
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MedLine Citation:
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PMID: 21281643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The medial preoptic nucleus (MPN) and ventral bed nuclei of the stria terminalis (BST) are needed to maintain mating in sexually experienced male gerbils and rats. The gerbil ventral BST is also activated with mating, as assessed by Fos expression, as is the medial MPN (MPNm) of both species. In gerbils, many of those mating-activated cells contain glutamic acid decarboxylase (GAD), the enzyme that synthesizes γ-aminobutyric acid (GABA). Some of those cells are projection neurons, but others may release GABA locally. Through actions in the medial preoptic area, GABA inhibits and testosterone (T) promotes male sex behavior. Thus, T may promote mating, in part, by decreasing GAD in MPNm or ventral BST cells. In rats, T increases GAD mRNA in the central MPN (MPNc), where MPN GABAergic cells are densest, but mating behavior does not change in sexually experienced males when the MPNc is ablated. Therefore, this study focused on the MPNm and ventral BST to ask whether their GABAergic cells respond to T or are sexually dimorphic. This was done by visualizing cells immunoreactive (IR) for GAD(67), an isoform found primarily in cell bodies, in male and female gerbils and in castrated males with and without T. At both sites, males had more GAD(67)-IR cells than females, and T decreased GAD(67)-IR cell numbers in males. Thus, the MPNm and ventral BST have GABAergic cells that are sexually dimorphic and in which T decreases GAD, consistent with local effects of T and GABA on mating. |
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Authors:
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Pauline Yahr |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-31 |
Journal Detail:
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Title: Hormones and behavior Volume: 59 ISSN: 1095-6867 ISO Abbreviation: Horm Behav Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-22 Completed Date: 2011-08-15 Revised Date: 2012-09-18 |
Medline Journal Info:
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Nlm Unique ID: 0217764 Medline TA: Horm Behav Country: United States |
Other Details:
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Languages: eng Pagination: 473-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurobiology and Behavior University of California, Irvine, CA 92697-4550, USA. piyahr@uci.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Androgens
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metabolism,
pharmacology* Animals Female Gerbillinae Glutamate Decarboxylase / metabolism Immunohistochemistry Male Neurons / drug effects*, metabolism Orchiectomy Preoptic Area / drug effects*, metabolism Random Allocation Septal Nuclei / drug effects*, metabolism Sex Characteristics* Sex Factors Testosterone / metabolism, pharmacology* gamma-Aminobutyric Acid / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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MH-26481/MH/NIMH NIH HHS; R01 MH026481-24/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 56-12-2/gamma-Aminobutyric Acid; 58-22-0/Testosterone; EC 4.1.1.15/Glutamate Decarboxylase; EC 4.1.1.15/glutamate decarboxylase 1 |
| Comments/Corrections | |
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