Document Detail

Sex difference in urethral response to electrical stimulation of efferent nerves in the pudendal sensory branch of rats.
MedLine Citation:
PMID:  12445238     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We reported sex difference in the urethral pressure (UP) response to electrical stimulation (ES) of the hypogastric nerve in rats. The purpose of the present study was to report on sex difference in the UP response to ES of the pudendal nerves (PN) in rats before and after injection of d-tubocurarine (d-tc). METHODS: Wistar rats were anesthetized with urethane and alpha-chloralose. The L6-S1 trunk was exposed on the left side and resected. After resection of the motor branch of the PN the peripheral end of the L6-S1 trunk was stimulated. Fluid was infused into the urethra through a catheter inserted into the bladder neck at a constant rate (0.5 mL/10 min) and the infusion resistance was measured as the UP. When d-tc was injected, the rats were ventilated with an artificial respirator. RESULTS: Though ES of the L6-S1 trunk caused fibrillation of the muscles near the tail and steep reduction of the UP, it caused elevation and reduction of UP in male and female rats, respectively, after intravenous injection of d-tc (0.3 mg/kg). ES of the sensory branch of the PN caused the elevation in male rats and reduction of the UP without injection of d-tc, and prazosin inhibited the UP elevation but the reduction was not inhibited by Nomega-nitro-L-arginine methyl ester. CONCLUSION: In the sensory branch of the PN, the nerves innervating the smooth muscles in the urethral sphincter were contained. In male rats norepinephrine mediates the UP elevation, but the neurotransmitter that mediates the UP reduction in female rats is not known.
Hitoshi Kontani; Chisato Shiraoya
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  9     ISSN:  0919-8172     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-26     Completed Date:  2003-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  586-95; discussion 596     Citation Subset:  IM    
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanagawa-machi, Kanazawa, Japan.
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MeSH Terms
Autonomic Agents / pharmacology*
Diagnostic Techniques, Urological
Efferent Pathways / drug effects*,  physiology
Electric Stimulation / methods*
Enzyme Inhibitors / pharmacology
Hexamethonium / pharmacology
Hypogastric Plexus / drug effects*,  physiology*
NG-Nitroarginine Methyl Ester / pharmacology
Nicotinic Antagonists / pharmacology*
Prazosin / pharmacology
Rats, Wistar
Sex Factors
Tubocurarine / pharmacology*
Urethra / physiology*
Urodynamics / drug effects,  physiology
Reg. No./Substance:
0/Autonomic Agents; 0/Enzyme Inhibitors; 0/Nicotinic Antagonists; 19216-56-9/Prazosin; 50903-99-6/NG-Nitroarginine Methyl Ester; 57-95-4/Tubocurarine; 60-26-4/Hexamethonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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