Document Detail


Sex difference in prolactin and growth hormone cells in mouse adenohypophysis: stereological, morphometric, and immunohistochemical studies by light and electron microscopy.
MedLine Citation:
PMID:  3293989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PRL and GH cells in the adenohypophysis of adult mice were studied with immunohistochemistry and stereological morphometry by light and electron microscopy. We compared findings for males and females. In female mice, most PRL-immunoreactive cells (43% of all parenchymal cells) and most GH-immunoreactive cells (33% of all parenchymal cells) were classical PRL cells (type I PRL cells) or GH cells (type I GH cells), respectively. Besides these classical types of cells, we found PRL- and GH-immunoreactive (type II PRL and GH) cells that contained small (approximately 100-200 nm in diameter) and round secretory granules. However, in female mice type II PRL or GH cells accounted for less than 3% of all parenchymal cells, as was also true for type II GH cells in the males. The percentages of type I and type II PRL cells in male mice were about the same (approximately 10% of all parenchymal cells). Only a few mammosomatotropes (0-0.6% of all parenchymal cells) were found in the mouse adenohypophysis of either sex. All mammosomatotropes were type II cells; none were PRL or GH cells of the classical type. This immunohistochemical study confirmed our previous findings by conventional electron microscopy that there are marked sex differences in the proportions of PRL and GH cells in the adult mouse adenohypophysis; PRL cells are more abundant in the female mice, and GH cells are more abundant in the males.
Authors:
F Sasaki; Y Iwama
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Endocrinology     Volume:  123     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-08-29     Completed Date:  1988-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  905-12     Citation Subset:  AIM; IM    
Affiliation:
Department of Veterinary Anatomy, University of Osaka Prefecture College of Agriculture, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Count
Cytoplasmic Granules / ultrastructure
Female
Growth Hormone / metabolism*
Histocytochemistry
Immunoenzyme Techniques
Male
Mice
Microscopy, Electron
Pituitary Gland, Anterior / cytology*,  metabolism
Prolactin / metabolism*
Sex Characteristics*
Chemical
Reg. No./Substance:
9002-62-4/Prolactin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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