| Sex difference in lipid profile in relation to the progression of glucose abnormalities. | |
| | |
MedLine Citation:
|
PMID: 21951548 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objectives: Since type 2 diabetes mellitus (DM2) abolishes the lower cardiovascular risk of females, we investigated the role played by changes in blood lipids. Methods: In 1091 consecutive subjects, 478 men and 613 women, we executed OGTT to subdivide them in: normal glucose tolerance (NGT, n=589); pre-diabetes (pre-DM2) including impaired fasting glucose (IFG, n=212), impaired glucose tolerance (IGT, n=84) and both (IFG/IGT, n=102); DM2 (n=104). In each subject we measured: total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, apolipoproteinA-I, apolipoproteinB, apoB/apoA-I ratio. We tested by Student's t test the statistical differences in lipids between men and women in each of the aforementioned groups. Results: NGT male subjects presented higher triglycerides and apoB/apoA-I ratio (p<0.0001), lower HDL-cholesterol and apoA-I (p<0.0001). The pre-DM2 men maintained a higher apoB/apoA-I ratio (p<0.05) and lower HDL-cholesterol (p<0.0001). In DM2 group only HDL-c was lower in men (p<0.05). Conclusions: The progression of glucose intolerance, from NGT to pre-DM2 and DM2, exhibits striking sex difference regarding the lipid profile. Our data demonstrate a worsening of plasma lipid composition in women who become diabetic. This could explain, at least in part, the loss of the more favourable cardiovascular risk present in NGT females. |
| | |
Authors:
|
Gian Piero Carnevale Schianca; Gian Paolo Fra; Elena Colli; Marcello Bigliocca; Roberto Mella; Elena Scaglia; Ettore Bartoli; |
Related Documents
:
|
12631178 - Assessment of periodontal conditions and systemic disease in older subjects. 18637388 - Oral health status of low-income, middle-aged to elderly hong kong chinese with type 2 ... 9005968 - Do non-insulin-dependent diabetes mellitus (niddm) and insulin-dependent diabetes melli... 20874828 - Cytokine levels in sites of chronic periodontitis of poorly controlled and well-control... 21868778 - Insulin pump therapy with automated insulin suspension in response to hypoglycemia: red... 21728808 - Proteasome modulator 9 gene is linked to diabetic and non-diabetic retinopathy in t2d. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-26 |
Journal Detail:
|
Title: Journal of diabetes Volume: - ISSN: 1753-0407 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101504326 Medline TA: J Diabetes Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Ruijin Hospital and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
|
Internal Medicine, Department of Clinical and Sperimental Medicine, University of Eastern Piedmont "A. Avogadro", Novara, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Methotrexate in the Management of Idiopathic Granulomatous Mastitis: Review of 108 Published Cases a...
Next Document: Octreotide for the treatment of diarrhea in patients with ileal pouch anal anastomosis: a placebo co...