| Sex-dependent modulation of treatment response. | |
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MedLine Citation:
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PMID: 22034399 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The response to a psychotropic medication reflects characteristics of both the medication and the substrate, ie, the individual receiving the medication. Sex is an individual characteristic that influences all elements of the pharmacokinetic process - absorption, distribution, metabolism, and elimination. The effects of sex on these components of the pharmacokinetic process often counterbalance one another to yield minimal or varying sexual differences in blood levels achieved. However, sex also appears to influence pharmacodynamics, the tissue response to a given level of medication. Consideration by the practitioner of sex as a possible contributing factor to treatment nonresponse will enhance the efficacy and precision of clinical interventions. |
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Authors:
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David R Rubinow; Molly Moore |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Dialogues in clinical neuroscience Volume: 6 ISSN: 1294-8322 ISO Abbreviation: Dialogues Clin Neurosci Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2011-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101238198 Medline TA: Dialogues Clin Neurosci Country: France |
Other Details:
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Languages: eng Pagination: 39-51 Citation Subset: - |
Affiliation:
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Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Md, USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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