Document Detail


Sex-dependent mechanisms for expansions and contractions of the CAG repeat on affected Huntington disease chromosomes.
MedLine Citation:
PMID:  7668260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 254 affected parent-child pairs with Huntington disease (HD) and 440 parent-child pairs with CAG size in the normal range were assessed to determine the nature and frequency of intergenerational CAG changes in the HD gene. Intergenerational CAG changes are extremely rare (3/440 [0.68%]) on normal chromosomes. In contrast, on HD chromosomes, changes in CAG size occur in approximately 70% of meioses on HD chromosomes, with expansions accounting for 73% of these changes. These intergenerational CAG changes make a significant but minor contribution to changes in age at onset (r2 = .19). The size of the CAG repeat influenced larger intergenerational expansions (> 7 CAG repeats), but the likelihood of smaller expansions or contractions was not influenced by CAG size. Large expansions (> 7 CAG repeats) occur almost exclusively through paternal transmission (0.96%; P < 10(-7)), while offspring of affected mothers are more likely to show no change (P = .01) or contractions in CAG size (P = .002). This study demonstrates that sex of the transmitting parent is the major determinant for CAG intergenerational changes in the HD gene. Similar paternal sex effects are seen in the evolution of new mutations for HD from intermediate alleles and for large expansions on affected chromosomes. Affected mothers almost never transmit a significantly expanded CAG repeat, despite the fact that many have similar large-sized alleles, compared with affected fathers. The sex-dependent effects of major expansion and contractions of the CAG repeat in the HD gene implicate different effects of gametogenesis, in males versus females, on intergenerational CAG repeat stability.
Authors:
B Kremer; E Almqvist; J Theilmann; N Spence; H Telenius; Y P Goldberg; M R Hayden
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of human genetics     Volume:  57     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-10-12     Completed Date:  1995-10-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-50     Citation Subset:  IM    
Affiliation:
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age of Onset
Base Sequence
Child
Child, Preschool
DNA / analysis
Fathers
Female
Humans
Huntington Disease / genetics*
Male
Middle Aged
Molecular Sequence Data
Mothers
Repetitive Sequences, Nucleic Acid*
Sex Factors
Chemical
Reg. No./Substance:
9007-49-2/DNA
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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