| Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats. | |
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MedLine Citation:
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PMID: 18093817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to investigate whether the protein and folic acid content of the maternal diet and the sex of the offspring alter the polyunsaturated fatty acid content of hepatic phospholipids and triacylglycerol (TAG). Pregnant rats were fed diets containing 18% or 9% protein with either 1 or 5mg/kg folic acid. Maternal diet did not alter hepatic lipid composition in the adult offspring. Data from each maternal dietary group were combined and reanalysed. The proportion of 18:0, 20:4n-6 and 22:6n-3 in liver phospholipids was higher in females than in males, while hepatic TAG composition did not differ between sexes. Delta5 Desaturase expression was higher in females than in males. Neither Delta5 nor Delta6 desaturase expression was related to polyunsaturated fatty acid concentrations. These results suggest that sex differences in liver phospholipid fatty acid composition may reflect primary differences in the specificity of phospholipid biosynthesis. |
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Authors:
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G C Burdge; J L Slater-Jefferies; R A Grant; W-S Chung; A L West; K A Lillycrop; M A Hanson; P C Calder |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 78 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-14 Completed Date: 2008-03-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 73-9 Citation Subset: IM |
Affiliation:
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Institute of Human Nutrition, Institute of Developmental Sciences Building, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, UK. g.c.burdge@soton.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Proteins / administration & dosage Fatty Acid Desaturases / metabolism Fatty Acids, Unsaturated / analysis* Female Folic Acid / administration & dosage Linoleoyl-CoA Desaturase / metabolism Liver / chemistry*, enzymology Male Phospholipids / chemistry* Pregnancy Rats Sex Characteristics* Triglycerides / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 0/Triglycerides; 59-30-3/Folic Acid; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.3/Linoleoyl-CoA Desaturase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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