| Sex, aging, and preexisting cerebral ischemic disease in patients with aortic stenosis. | |
| | |
MedLine Citation:
|
PMID: 20868818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Patients undergoing cardiac surgery have a high frequency of preexisting cerebral ischemic lesions, the presence of which appears to predict cognitive sequelae. Patients undergoing aortic valve replacement for aortic stenosis (AS) incur an exceptionally high risk for perioperative cerebral ischemia. The extreme risk in this subgroup may arise from the preexisting burden of cerebral ischemic disease. We tested the hypotheses that increasing age, female sex, coronary artery disease, and the severity of AS are predictive of the severity of preexisting cerebral ischemic lesions. METHODS: A total of 95 subjects were included in this study. Subjects were imaged on 1.5 Tesla magnetic resonance imaging scanners to obtain multimodal image sets which were used for the automatic segmentation of cerebral lesion volume. The dependence of lesion volume upon age, sex, coronary artery disease, and the severity of AS were tested. RESULTS: The results demonstrate a strong correlation between aging, female sex, and white matter and ischemia-like lesion volume in patients with aortic stenosis. CONCLUSIONS: Women and those of advanced age presenting for aortic valve replacement for AS may incur a particularly high risk for postoperative neurologic sequelae due to an exceptional preexisting burden of cerebral ischemic disease. |
| | |
Authors:
|
Ping Wang; Michael A Acker; Michel Bilello; Elias R Melhem; Elizabeth Stambrook; Sarah J Ratcliffe; Thomas F Floyd; |
Related Documents
:
|
8077798 - Collateral role of the external carotid artery and its branches in occlusion of the int... 7545328 - Continuous retrograde cerebral perfusion aids repair of aortic laceration during sterna... 3673498 - Vascular dementia due to cardiac arrhythmias and systemic hypotension. 4010928 - Pre-optic origin of the anterior cerebral artery. 16762768 - A rare complication of atrial septal occluders: diagnosis by transthoracic echocardiogr... 9510278 - Accuracy of duplex ultrasound in evaluating carotid artery anatomy before endarterectomy. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: The Annals of thoracic surgery Volume: 90 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-27 Completed Date: 2010-10-21 Revised Date: 2012-05-07 |
Medline Journal Info:
|
Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 1230-5 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Radiology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Aged Aged, 80 and over Aging Aortic Valve Stenosis / epidemiology*, surgery* Brain Ischemia / diagnosis, epidemiology*, etiology Cognition Disorders / etiology* Comorbidity Female Heart Valve Prosthesis Implantation / adverse effects* Humans Magnetic Resonance Imaging Male Risk Assessment Risk Factors Severity of Illness Index Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL084375-03/HL/NHLBI NIH HHS; R01HL084375/HL/NHLBI NIH HHS |
| Investigator | |
Investigator/Affiliation:
|
Michael A Acker / ; Joseph E Bavaria / ; Thomas F Floyd / ; Tania Giovanetti / ; W Clark Hargrove / ; Scott E Kasner / ; William H Matthai / ; Elias R Melhem / ; Emile R Mohler / ; Rohinton J Morris / ; Alberto A Pochettino / ; Catherine E C Price / ; Sarah J Ratcliffe / ; Ola A Selnes / ; Wilson Y Szeto / ; Y Joseph Woo / ; Susan E Wiegers / ; Nimesh D Desai / ; Martin G Keane / |
| Comments/Corrections | |
Comment In:
|
Ann Thorac Surg. 2010 Oct;90(4):1235-6
[PMID:
20868819
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predicting hospital mortality and analysis of long-term survival after major noncardiac complication...
Next Document: Invited commentary.