Document Detail

Sex- and age-related differences in the prognostic value of C-reactive protein in patients with angiographic coronary artery disease.
MedLine Citation:
PMID:  15501203     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine whether sex and age affect serum C-reactive protein level and its prognostic value in patients with coronary artery disease. METHODS: In a consecutive series of 2254 patients with angiographically defined coronary artery disease, baseline C-reactive protein and predictive value for incident death or nonfatal myocardial infarction by sex and age (<55 and > or =55 years) were compared. C-reactive protein levels were measured by fluorescence polarization immunoassay with use of a medium-sensitivity method. Patients were followed for a mean (+/-SD) of 3.1 +/- 2.2 years. Comparisons used ln-transformed C-reactive protein and linear and time-to-event regression analyses, adjusting for confounders. RESULTS: Overall, women had higher geometric mean C-reactive protein levels than did men (1.47 vs. 1.30 mg/dL, P <0.001), even after adjustment for age, hyperlipidemia, diabetes, prior myocardial infarction, body mass index, and heart failure (P = 0.002). High C-reactive protein levels were associated with increased mortality or myocardial infarction among men (adjusted hazard ratio [HR] = 1.9; 95% confidence interval [CI]: 1.5 to 2.3) but not among women (HR = 1.0; 95% CI: 0.69 to 1.4). Among patients aged <55 years, C-reactive protein level was similarly predictive in men and women (HR = 2.2 vs. 2.7), whereas in patients > or =55 years of age, it remained predictive for men (HR = 1.8; 95% CI: 1.5 to 2.3) but not women (HR = 0.93; 95% CI: 0.63 to 1.4). CONCLUSION: We found that the prognostic value of C-reactive protein in coronary artery disease patients varied by sex and age. This sex-age interaction may have important implications for C-reactive protein-based secondary risk assessment and requires further investigation.
Lillian L C Khor; Joseph B Muhlestein; John F Carlquist; Benjamin D Horne; Tami L Bair; Chloe A Maycock; Jeffrey L Anderson;
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of medicine     Volume:  117     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-25     Completed Date:  2004-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  657-64     Citation Subset:  AIM; IM    
Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
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MeSH Terms
Age Factors
C-Reactive Protein / analysis*
Coronary Angiography
Coronary Disease / blood*,  diagnosis*
Multivariate Analysis
Predictive Value of Tests
Proportional Hazards Models
Risk Factors
Sex Factors
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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