| Sex Steroids effects in Normal Endocrine Pancreatic Function and Diabetes. | |
| | |
MedLine Citation:
|
PMID: 21463250 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Traditionally the role of sexual steroid hormones was focused primarily on reproductive organs: the breast, female reproductive tract (uterus, mammary gland, and ovary), and male reproductive tract (testes, epididymis and prostate), however our current understanding of tissue-specific effects of sex steroids has elucidated new aspects in its functionality. Recent data have shown that many other tissues are targets of those hormones in addition to classical reproductive organs. The pancreas (which performs both endocrine and exocrine functions), has proven to be an extragonadal target of sexual steroid hormone action. The endocrine pancreas has a pivotal role on carbohydrate homeostasis and deterioration in function produces diabetes. Diabetes is a metabolic disorder that has high prevalence worldwide, particularly in developing countries. It has been shown that steroid hormones have an important role in susceptibility and development of diabetes in animal models, in humans its role is less clear, however the most evident effect is on the perimenopausal women, in this stage the decrease in gonadal steroids produces an increase on susceptibility to develop diabetes mellitus; in men, hipoandrogenism is associated with an increased prevalence of insulin resistance. This review focused on the effects of sexual steroids on pancreatic function and diabetes. |
| | |
Authors:
|
Sumiko Morimoto; Francisco Jiménez-Trejo; Marco Cerbón |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-5 |
Journal Detail:
|
Title: Current topics in medicinal chemistry Volume: - ISSN: 1873-4294 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101119673 Medline TA: Curr Top Med Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Instituto Nacional de Ciencias Médicas y Nutrición, S.Z., Vasco de Quiroga 15, CP. 14000, México, sumiko.morimotom@quetzal.innsz.mx. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Single Pill to Treat Postmenopausal Hypertension? Not Yet.
Next Document: Non-Reproductive Effects of Sex Steroids: Their Immunoregulatory Role.