Document Detail

Sex Differences in Newborn Myocardial Metabolism and Response to Ischemia.
MedLine Citation:
PMID:  21532527     Owner:  NLM     Status:  Publisher    
In children with congenital heart disease, female sex has been linked to greater in-hospital mortality associated with low cardiac output, yet the reasons for this are unclear. Therefore, we examined whether newborn sex differences in the heart's metabolic response to ischemia exist. Left ventricular (LV) in vivo and ischemic biopsies of newborn male and female piglets were compared. Tissue adenosine triphosphate (ATP), creatine phosphate (CP), glycogen, anaerobic end-products lactate and hydrogen ion (H), and key regulatory enzymes were measured. Compared to males, newborn females displayed 14% lower ATP, 22% lower CP and 32% lower glycogen reserves (p<0.05) at baseline. During ischemia, newborn females accumulated 17% greater lactate and 40% greater H accumulation (p<0.02) which was associated with earlier cessation of glycolysis and lower ischemic ATP levels (p<0.02) compared to males. Newborn females demonstrated a greater ability to utilize their glycogen reserves, resulting in significantly lower (p<0.003) glycogen levels throughout the ischemic period. Thus, newborn females are at a metabolic disadvantage as they exhibited lower energy levels and greater tissue lactic acidosis, both linked to an increase susceptibility to ischemic injury and impair myocardial function upon reperfusion. ABBREVIATIONS::
Carin Wittnich; Danny Quaglietta; Luke Tan; Michael P Belanger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-28
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Physiology [C.W., D.Q., L.T.], University of Toronto, Toronto, ON, M5S 1A8, Canada; Department of Surgery [C.W., M.P.B.], University of Toronto, Toronto, ON, M5G 1L5, Canada.
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