Document Detail


Sex Differences in the Biomechanics and Contractility of Intramural Coronary Arteries in Angiotensin II-Induced Hypertension.
MedLine Citation:
PMID:  23217570     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: It is well known that sex differences occur in both the pathogenesis and therapy of hypertension. A deeper understanding of the underlying processes may be helpful when planning a personalized therapeutic strategy.
OBJECTIVE: In laboratory animal experiments, we studied the early mechanisms of vascular adaptation of the intramural small coronary arteries that play a fundamental role in the blood supply of the heart.
METHODS: In our study, an osmotic minipump was implanted into 10 male and 10 female Sprague-Dawley rats. The pump remained in situ for 4 weeks, infusing a dose of 100 ng/kg/min angiotensin II acetate. Four weeks later, the animals were killed, and the intramural coronary arteries from the left coronary branch, which are fundamentally responsible for the blood supply of the heart, were prepared. The pharmacologic reactivity and biomechanical properties of the prepared segments were studied in a tissue bath.
RESULTS: The relative heart mass and vessel wall thickness were greater in females than males (0.387 [0.009] g/100 g vs 0.306 [0.006] g/100 g body weight; 41.9 [4.09] μm vs 33.45 [3.37] μm on 50 mm Hg). The vessel tone and vasoconstriction in response to thromboxane agonists were, however, significantly more pronounced in males. The extent of relaxation in response to bradykinin was also greater in females. Although we observed inward eutrophic remodeling in females, an increase in wall stress and elastic modulus dominated in males.
CONCLUSION: The early steps of angiotensin II-dependent hypertension evoked very different adaptation mechanisms in males and females.
Authors:
Máté Mátrai; Judit Hetthéssy; György L Nádasy; Emil Monos; Béla Székács; Szabolcs Várbíró
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gender medicine     Volume:  9     ISSN:  1878-7398     ISO Abbreviation:  Gend Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101225178     Medline TA:  Gend Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  548-56     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2012. Published by EM Inc USA. All rights reserved.
Affiliation:
Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Faculty of Medicine, Budapest, Hungary. Electronic address: mate@matrai.org.
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