| Sex Differences in the Association between Level of Childhood Interleukin-6 and Insulin Resistance in Adolescence. | |
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MedLine Citation:
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PMID: 22272193 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The purpose of this study was to determine whether levels of interleukin-6 (IL-6) in childhood are related to insulin resistance in adolescence. Further, to explore how fatness and cardiorespiratory fitness (VO(2peak)) moderate this relationship. Methods. 292 nine-year-old children (n = 292) were followed for 4 years. Anthropometrics and VO(2peak) were measured. Fasting blood samples were analyzed for IL-6, insulin, and glucose. Homeostasis model assessment (HOMA-IR) was used as a measure of insulin resistance. Results. For girls but not boys, levels of IL-6 at age 9 yrs correlated with HOMA-IR at age 13 yrs: r = 0.223, P = 0.008. Girls with IL-6 levels within the highest quartile at age 9 yrs had an odds ratio of 3.68 (CI = 1.58-8.57) being in the highest quartile of HOMA-IR four years later. Conclusion. In this cohort, IL-6 levels in childhood were related to insulin resistance in adolescence, but only for girls. |
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Authors:
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Anna Bugge; Bianca El-Naaman; Robert G McMurray; Karsten Froberg; Claus Henrik Nielsen; Klaus Müller; Lars Bo Andersen |
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Publication Detail:
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Type: Journal Article Date: 2012-01-05 |
Journal Detail:
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Title: Experimental diabetes research Volume: 2012 ISSN: 1687-5303 ISO Abbreviation: Exp Diabetes Res Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101274844 Medline TA: Exp Diabetes Res Country: United States |
Other Details:
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Languages: eng Pagination: 859186 Citation Subset: IM |
Affiliation:
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Centre for Research in Childhood Health, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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