Document Detail

Sevoflurane versus halothane: postoperative maladaptive behavioral changes: a randomized, controlled trial.
MedLine Citation:
PMID:  15791099     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The authors conducted a double-blind, randomized, controlled trial to determine whether the use of sevoflurane in children undergoing anesthesia and surgery results in a higher incidence of postoperative maladaptive behavioral changes as compared with halothane. METHODS: Children and their parents (n = 102) were randomly assigned to either a halothane group (n = 50) or a sevoflurane group (n = 52). The intraoperative anesthetic protocol was strictly controlled, and the postoperative analgesic consumption and pain levels were recorded. The effect of the group assignment on emergence status and maladaptive postoperative behavioral changes was assessed both by validated psychological measures and physiologic instruments (actigraphy) on postoperative days 1-7. Anxiety of the parent and child was also assessed, as was the child's postoperative recovery (Recovery Inventory). RESULTS: There were no group differences in preoperative state anxiety, postoperative analgesic requirements, postoperative pain, or the incidence of emergence delirium (P = not significant). Two-way repeated-measures analysis of variance showed no group differences in the incidence of postoperative maladaptive behaviors (F4,72 = 0.60, P = 0.701) or actigraphic variables such as percent sleep, number of night awakenings, and night awakenings that lasted for more than 5 min (P = not significant). CONCLUSION: The authors found no increased incidence of emergence delirium, maladaptive postoperative behavior changes, or sleep disturbances in children undergoing anesthesia with sevoflurane as compared with halothane.
Zeev N Kain; Alison A Caldwell-Andrews; Megan E Weinberg; Linda C Mayes; Shu-Ming Wang; Dorothy Gaal; Haleh Saadat; Inna Maranets
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  102     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-25     Completed Date:  2005-05-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-6     Citation Subset:  AIM; IM    
Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
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MeSH Terms
Ambulatory Surgical Procedures
Anesthesia Recovery Period
Anesthetics, Inhalation / adverse effects*
Anxiety / psychology
Child Behavior Disorders / chemically induced*,  psychology
Child, Preschool
Delirium / chemically induced,  psychology
Double-Blind Method
Halothane / adverse effects*
Methyl Ethers / adverse effects*
Motor Activity / drug effects
Pain, Postoperative / psychology
Postoperative Complications / chemically induced*,  psychology*
Psychiatric Status Rating Scales
Sleep / drug effects
Temperament / drug effects
Treatment Outcome
Grant Support
R01 HD 37007-02/HD/NICHD NIH HHS
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 151-67-7/Halothane; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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