Document Detail

Sevoflurane impairs memory consolidation in rats, possibly through inhibiting phosphorylation of glycogen synthase kinase-3β in the hippocampus.
MedLine Citation:
PMID:  20807582     Owner:  NLM     Status:  MEDLINE    
Sevoflurane administration impairs memory processes in both humans and animals. Increasing evidence suggests that enhancement of the phosphorylation state of glycogen synthase kinase-3β (GSK-3β), as a result of acute administration of lithium chloride (LiCl), may enhance memory consolidation. The current experiments examined whether GSK-3β phosphorylation was involved in mediating the memory impairing effects of posttraining sevoflurane on inhibitory avoidance (IA) retention. In experiment 1, adult male Sprague-Dawley rats were exposed to sevoflurane (0.5%, 1%, or 2%) for 2h immediately after training in a continuous multiple-trail IA paradigm. Sevoflurane (2% inspired) induced significant impairment of retention performance on a 24-h test and inhibited phosphorylation of GSK-3β in the hippocampus 2h after training. In experiment 2, administration of LiCl (100mg/kg, intraperitoneally) 30 min before IA training not only blocked the sevoflurane-induced impairment of consolidation, but also reversed the inhibitory effect of sevoflurane on GSK-3β phosphorylation in the hippocampus. Collectively, these findings support the hypothesis that sevoflurane exposure can impair consolidation of IA memory in rats. Sevoflurane-induced amnesia may be due, at least in part, to suppression of GSK-3β phosphorylation in the hippocampus.
Xue-Sheng Liu; Qing-sheng Xue; Qing-Wen Zeng; Qian Li; Jian Liu; Xiao-Mei Feng; Bu-Wei Yu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-31
Journal Detail:
Title:  Neurobiology of learning and memory     Volume:  94     ISSN:  1095-9564     ISO Abbreviation:  Neurobiol Learn Mem     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2011-02-28     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  9508166     Medline TA:  Neurobiol Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  461-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Anesthesiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, PR China.
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MeSH Terms
Analysis of Variance
Anesthetics, Inhalation / pharmacology*
Avoidance Learning / drug effects*
Dose-Response Relationship, Drug
Enzyme Inhibitors / pharmacology
Glycogen Synthase Kinase 3 / drug effects,  metabolism*
Hippocampus / drug effects*,  enzymology
Lithium Chloride / pharmacology
Maze Learning / drug effects
Memory / drug effects*
Methyl Ethers / pharmacology*
Phosphorylation / drug effects
Statistics, Nonparametric
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Enzyme Inhibitors; 0/Methyl Ethers; 28523-86-6/sevoflurane; 7447-41-8/Lithium Chloride; EC synthase kinase 3 beta; EC Synthase Kinase 3

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