Document Detail

Sevoflurane is epileptogenic in healthy subjects at surgical levels of anesthesia.
MedLine Citation:
PMID:  14581667     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate EEG effects of three escalating concentrations of sevoflurane and propofol in single-agent anesthesia on healthy subjects. METHODS: Four-channel EEG was continuously recorded at 1, 1.5, and 2 minimum alveolar concentration (MAC)/effective plasma concentration 50 (EC50) levels of either sevoflurane or propofol anesthesia in 16 men, 8 subjects in each group. Each concentration level lasted for 30 minutes. EEG was first visually analyzed. In quantitative EEG analysis, the 95% spectral edge frequency (SEF95) and peak frequency (PF) were determined after fast Fourier transformation. RESULTS: Epileptiform discharges occurred in all eight subjects at 1.5 and 2 MAC levels of sevoflurane anesthesia. Three subjects showed electrographic seizures at 2 MAC level, in one case accompanied with clinical seizures despite muscle relaxation. Propofol did not produce remarkable epileptiform EEG phenomena at any level of anesthesia. Suppression and slowing of EEG activity were evident for both drugs with increasing concentration. Owing to the high incidence of epileptiform events in the sevoflurane group at 1.5 and 2 MAC, the SEF95 and PF values were higher (p < 0.001) compared with propofol. Within the sevoflurane group, these values were higher at the 2 than at the 1.5 MAC level (p values ranged between <0.001 and 0.019). CONCLUSIONS: Sevoflurane consistently produces epileptiform discharges and is dose dependently epileptogenic at surgical levels of anesthesia.
S K Jääskeläinen; K Kaisti; L Suni; S Hinkka; H Scheinin
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Neurology     Volume:  61     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-28     Completed Date:  2004-09-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1073-8     Citation Subset:  AIM; IM    
Department of Clinical Neurophysiology, and Turku PET Centre, Finland.
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MeSH Terms
Anesthesia / adverse effects*,  methods
Anesthetics, Inhalation / administration & dosage,  adverse effects*
Anesthetics, Intravenous / administration & dosage
Brain / drug effects,  radionuclide imaging
Dose-Response Relationship, Drug
Electroencephalography / drug effects*
Epilepsy / chemically induced*,  diagnosis
Methyl Ethers / administration & dosage,  adverse effects*
Propofol / administration & dosage
Prospective Studies
Reference Values
Tomography, Emission-Computed
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Methyl Ethers; 2078-54-8/Propofol; 28523-86-6/sevoflurane
Comment In:
Neurology. 2004 Jun 22;62(12):2335; author reply 2335   [PMID:  15210918 ]

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