Document Detail

Sevoflurane confers additional cardioprotection after ischemic late preconditioning in rabbits.
MedLine Citation:
PMID:  12960546     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sevoflurane exerts cardioprotective effects that mimic the early ischemic preconditioning phenomenon (EPC) by activating adenosine triphosphate-sensitive potassium (KATP) channels. Ischemic late preconditioning (LPC) is an important cardioprotective mechanism in patients with coronary artery disease. The authors investigated whether the combination of LPC and sevoflurane-induced preconditioning results in enhanced cardioprotection and whether opening of KATP channels plays a role in this new setting. METHODS: Seventy-three rabbits were instrumented with a coronary artery occluder. After recovery for 10 days, they were subjected to 30 min of coronary artery occlusion and 120 min of reperfusion (I/R). Controls (n = 14) were not preconditioned. LPC was induced in conscious animals by a 5-min period of coronary artery occlusion 24 h before I/R (LPC, n = 15). Additional EPC was induced by a 5-min period of myocardial ischemia 10 min before I/R (LPC+EPC, n = 9). Animals of the sevoflurane (SEVO) groups inhaled 1 minimum alveolar concentration of sevoflurane for 5 min at 10 min before I/R with (LPC+SEVO, n = 10) or without (SEVO, n = 15) additional LPC. The KATP channel blocker 5-hydroxydecanoate (5-HD, 5 mg/kg) was given intravenously 10 min before sevoflurane administration (LPC+SEVO+5-HD, n = 10). RESULTS: Infarct size of the area at risk (triphenyltetrazolium staining) was reduced from 45 +/- 16% (mean+/-SD, control) to 27 +/- 11% by LPC (P < 0.001) and to 27 +/- 17% by sevoflurane (P = 0.001). Additional sevoflurane administration after LPC led to a further infarct size reduction to 14 +/- 8% (LPC+SEVO, P = 0.003 vs. LPC; P = 0.032 vs. SEVO), similar to the combination of LPC and EPC (12 +/- 8%; P = 0.55 vs. LPC+SEVO). Cardioprotection induced by LPC+SEVO was abolished by 5-HD (LPC+SEVO+5-HD, 41 +/- 19%, P = 0.001 vs. LPC+SEVO). CONCLUSIONS: Sevoflurane administration confers additional cardioprotection after LPC by opening of KATP channels.
Jost Müllenheim; Dirk Ebel; Mirco Bauer; Florian Otto; André Heinen; Jan Frässdorf; Benedikt Preckel; Wolfgang Schlack
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  99     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-08     Completed Date:  2003-09-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  624-31     Citation Subset:  AIM; IM    
Klinik für Anaesthesiologie, Universitätsklinikum, Duesseldorf, Germany.
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MeSH Terms
ATP-Binding Cassette Transporters
Anesthetics, Inhalation / pharmacology*
Blood Pressure / drug effects
Coronary Vessels / physiology
Decanoic Acids / pharmacology
Heart Diseases / prevention & control*
Heart Rate / drug effects
Hemodynamics / drug effects
Hydroxy Acids / pharmacology
Ischemic Preconditioning, Myocardial*
Methyl Ethers / pharmacology*
Mitochondria, Heart / drug effects,  metabolism
Myocardial Infarction / pathology,  prevention & control
Potassium Channels / drug effects,  metabolism
Potassium Channels, Inwardly Rectifying
Pulmonary Alveoli / drug effects,  metabolism
Vascular Resistance / drug effects
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/ATP-Binding Cassette Transporters; 0/Anesthetics, Inhalation; 0/Decanoic Acids; 0/Hydroxy Acids; 0/Methyl Ethers; 0/Potassium Channels; 0/Potassium Channels, Inwardly Rectifying; 0/uK-ATP-1 potassium channel; 28523-86-6/sevoflurane; 624-00-0/5-hydroxydecanoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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