| Sevoflurane confers additional cardioprotection after ischemic late preconditioning in rabbits. | |
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MedLine Citation:
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PMID: 12960546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sevoflurane exerts cardioprotective effects that mimic the early ischemic preconditioning phenomenon (EPC) by activating adenosine triphosphate-sensitive potassium (KATP) channels. Ischemic late preconditioning (LPC) is an important cardioprotective mechanism in patients with coronary artery disease. The authors investigated whether the combination of LPC and sevoflurane-induced preconditioning results in enhanced cardioprotection and whether opening of KATP channels plays a role in this new setting. METHODS: Seventy-three rabbits were instrumented with a coronary artery occluder. After recovery for 10 days, they were subjected to 30 min of coronary artery occlusion and 120 min of reperfusion (I/R). Controls (n = 14) were not preconditioned. LPC was induced in conscious animals by a 5-min period of coronary artery occlusion 24 h before I/R (LPC, n = 15). Additional EPC was induced by a 5-min period of myocardial ischemia 10 min before I/R (LPC+EPC, n = 9). Animals of the sevoflurane (SEVO) groups inhaled 1 minimum alveolar concentration of sevoflurane for 5 min at 10 min before I/R with (LPC+SEVO, n = 10) or without (SEVO, n = 15) additional LPC. The KATP channel blocker 5-hydroxydecanoate (5-HD, 5 mg/kg) was given intravenously 10 min before sevoflurane administration (LPC+SEVO+5-HD, n = 10). RESULTS: Infarct size of the area at risk (triphenyltetrazolium staining) was reduced from 45 +/- 16% (mean+/-SD, control) to 27 +/- 11% by LPC (P < 0.001) and to 27 +/- 17% by sevoflurane (P = 0.001). Additional sevoflurane administration after LPC led to a further infarct size reduction to 14 +/- 8% (LPC+SEVO, P = 0.003 vs. LPC; P = 0.032 vs. SEVO), similar to the combination of LPC and EPC (12 +/- 8%; P = 0.55 vs. LPC+SEVO). Cardioprotection induced by LPC+SEVO was abolished by 5-HD (LPC+SEVO+5-HD, 41 +/- 19%, P = 0.001 vs. LPC+SEVO). CONCLUSIONS: Sevoflurane administration confers additional cardioprotection after LPC by opening of KATP channels. |
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Authors:
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Jost Müllenheim; Dirk Ebel; Mirco Bauer; Florian Otto; André Heinen; Jan Frässdorf; Benedikt Preckel; Wolfgang Schlack |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesiology Volume: 99 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-08 Completed Date: 2003-09-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 624-31 Citation Subset: AIM; IM |
Affiliation:
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Klinik für Anaesthesiologie, Universitätsklinikum, Duesseldorf, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters Anesthetics, Inhalation / pharmacology* Animals Blood Pressure / drug effects Coronary Vessels / physiology Decanoic Acids / pharmacology Heart Diseases / prevention & control* Heart Rate / drug effects Hemodynamics / drug effects Hydroxy Acids / pharmacology Ischemic Preconditioning, Myocardial* Methyl Ethers / pharmacology* Mitochondria, Heart / drug effects, metabolism Myocardial Infarction / pathology, prevention & control Potassium Channels / drug effects, metabolism Potassium Channels, Inwardly Rectifying Pulmonary Alveoli / drug effects, metabolism Rabbits Vascular Resistance / drug effects Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/ATP-Binding Cassette Transporters; 0/Anesthetics, Inhalation; 0/Decanoic Acids; 0/Hydroxy Acids; 0/Methyl Ethers; 0/Potassium Channels; 0/Potassium Channels, Inwardly Rectifying; 0/uK-ATP-1 potassium channel; 28523-86-6/sevoflurane; 624-00-0/5-hydroxydecanoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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