Document Detail


Sevoflurane for central venous catheterization in non-intubated neonates.
MedLine Citation:
PMID:  19205649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Sedation in neonates undergoing invasive prodedures as central venous catheterization (CVC) remains contro versial. Sevoflurane is an inhaled anesthetic whose periods of action and elimination are very short. The objective of this study was to evaluate the use of sevoflurane for sedation for central venous catheterization (CVC) in non-intubated neonates and preterms. METHODS: Thirty three (33) consecutive patients (range: 1-31 days old, 26 to 40 weeks GA, weighing 580 to 3200 g) were included over a 4 months period. Sevoflurane was progressively increased, until loss of consciousness and motor response to stimulation. FiO(2), heart rate (HR), mean arterial pressure (MAP), duration of the procedure and the ease of the procedure were recorded. RESULTS: HR was very stable, but MAP dropped significantly. No patient required intubation. The ease of the procedure was scored as average 13 times and excellent 20 times. CONCLUSION: The use of sevoflurane in neonates for CVC is feasible and achieve the goals of procedural sedation. The pharmacokinetic of sevoflurane enabled rapid adjustment of the depth of sedation. Sevoflurane appears to be a new agent at the disposal of neonatologists. Its use does not come without risks, especially for smaller preterms, which the treating clinician must anticipate.
Authors:
Renaud Vialet; Fabrice Michel; Sophie Hassid; Jean-Noël Di Marco; Claude Martin
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-02-10
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  76     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-07-01     Revised Date:  2009-07-15    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Pediatric and Neonatal Intensive Care Unit, North University Hospital, Marseille, France. renaud.vialet@ap-hm.fr
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Inhalation / adverse effects,  pharmacokinetics,  pharmacology*
Blood Pressure / drug effects
Catheterization, Central Venous*
Deep Sedation
Dose-Response Relationship, Drug
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Infant, Newborn
Infant, Premature
Methyl Ethers / adverse effects,  pharmacokinetics,  pharmacology*
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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