Document Detail

Sevoflurane as a single anesthetic and physostigmine failure to enhance arousal.
MedLine Citation:
PMID:  17006419     Owner:  NLM     Status:  MEDLINE    
AIM: Sevoflurane is recommended for inhalational induction of anesthesia. Physostigmine may antagonize general anesthetics. The study investigates sevoflurane as a single anesthetic and its possible antagonism by physostigmine. METHODS: In 60 women scheduled for breast lump excision, anesthesia was induced with 8% sevoflurane. After 3 min of sevoflurane inhalation, a laryngeal mask airway (LMA) was inserted. Anesthesia was maintained with spontaneous ventilation at end tidal sevoflurane 3%. Systolic and diastolic blood pressure, heart rate and end tidal CO(2) were recorded intraoperatively. After skin closure and at end tidal sevoflurane 0.9%, physostigmine 2 mg or normal saline was given. After 2 min systolic, diastolic blood pressure, heart rate and end tidal CO(2) were recorded and sevoflurane was discontinued. Time to eyes opening, LMA removal and verbal response was recorded. Patients were also assessed for orientation, sedation, sitting ability and the ''picking up matches'' test at 0, 15 and 30 min after LMA removal. RESULTS: Systolic, diastolic blood pressure and heart rate increased after laryngeal mask placement (P=0.0001, P=0.0001 and P=0.0001, respectively). Orientation, sitting ability and ''picking up'' matches were similar in the 2 groups. Sedation at 15 min was less in the control group (P=0.004). CONCLUSIONS: Sevoflurane can be used as a single anesthetic but its recovery is not enhanced by physostigmine.
A Paraskeva; G Petropoulos; I Siafaka; A Fassoulaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Minerva anestesiologica     Volume:  72     ISSN:  0375-9393     ISO Abbreviation:  Minerva Anestesiol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-28     Completed Date:  2007-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375272     Medline TA:  Minerva Anestesiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  821-6     Citation Subset:  IM    
Anesthesiology Unit, Aretaieion Hospital, Athens, Greece.
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MeSH Terms
Anesthetics, Inhalation*
Antidotes / therapeutic use*
Arousal / drug effects*
Blood Pressure / drug effects
Breast Neoplasms / diagnosis,  pathology
Heart Rate / drug effects
Methyl Ethers*
Physostigmine / therapeutic use*
Respiratory Mechanics / drug effects
Treatment Failure
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Antidotes; 0/Methyl Ethers; 28523-86-6/sevoflurane; 57-47-6/Physostigmine

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