Document Detail

Sevoflurane anesthesia decreases cardiac vagal activity and heart rate variability.
MedLine Citation:
PMID:  17767378     Owner:  NLM     Status:  MEDLINE    
We evaluated cardiac vagal activity during sevoflurane anesthesia in neurosurgical patients. Heart rate variability was determined by power spectral analysis and entropy with the patient awake and during sevoflurane anesthesia. High frequency power (0.15-0.50 Hz) and heart rate entropy decreased during sevoflurane and these effects were significantly correlated (r = 0.71 +/- 0.12, P < 0.05). The results confirm that cardiac vagal activity was the primary determinant of heart rate variability, which was attenuated by sevoflurane.
Chanannait Paisansathan; Michael Lee; William E Hoffman; Peggy Wheeler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-31
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  17     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-14     Completed Date:  2008-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  370-4     Citation Subset:  IM    
Anesthesiology Department, University of Illinois at Chicago, 1740 W Taylor, Suite 3200, Chicago, IL 60612, USA.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Blood Pressure / drug effects*,  physiology
Heart Rate / drug effects*,  physiology
Methyl Ethers / pharmacology*
Vagus Nerve / drug effects*,  physiology
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane

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