Document Detail

Severity of obstetric complications and risk of adult schizophrenia in male patients: a case-control study.
MedLine Citation:
PMID:  14563090     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Obstetric complications may be an etiologically important factor in the development of schizophrenia. The aim of this study was to evaluate whether the risk for developing schizophrenia in adult life is increased in individuals with more severe obstetric complications at birth. METHODS: To this end, mothers were interviewed to gather data about obstetric complications. The 'midwife protocol' of Parnas and colleagues was used to quantify the presence and entity of obstetric complications. We studied the frequency distribution and the severity of obstetric complications in 64 male DSM IV schizophrenic patients. The genetic load was reduced by using 81 brothers who were not psychiatric patients as controls. Odds ratios for the effects of obstetric complications, maternal age, birth order and birth weight were calculated using conditional logistic regression. RESULTS: The only factor found to have a significant effect on the risk of schizophrenia was the overall measure of obstetric complications at birth. The history of obstetric complications was higher in schizophrenic patients than in their siblings. CONCLUSION: The results seem to confirm the hypothesis that obstetric complications may contribute to increased vulnerability to the disease, in addition to genetic risk factors.
G Bersani; I Taddei; G Manuali; L Ramieri; P Venturi; J Osborn; P Pancheri
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  14     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-10-17     Completed Date:  2003-11-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  IM    
Department of Psychiatric Sciences and Psychological Medicine, University La Sapienza, 3rd Psychiatric Clinic, Rome, Italy.
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MeSH Terms
Birth Order
Birth Weight
Brain Damage, Chronic / complications*,  pathology
Case-Control Studies
Injury Severity Score
Logistic Models
Maternal Age
Obstetric Labor Complications*
Odds Ratio
Risk Factors
Schizophrenia / etiology*,  genetics

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