Document Detail

Severity in myocardial dysfunction contributed to long-term fluctuation of heart rate, rather than short-term fluctuations.
MedLine Citation:
PMID:  12848794     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is known that heart rate shows complex behavior, long-term fluctuation of heart rate, and short-term fluctuations in heart failure. Analyzing these properties and examining the relationship to the disease, severity may increase the understanding of the background of heart rate variability (HRV). METHODS: In 61 patients (mean age 65 +/- 9 years, 32 ischemic heart disease, 29 cardiomyopathy), with myocardial dysfunction, 24-hour ambulatory electrocardiography was performed. After the construction of the time series of R-R intervals, 15 HRV parameters were measured, including mean heart rate, standard deviation of N-N intervals (SDNN), ratio of low frequency/high frequency power (LF/HF), HRV triangular index (TI), and ratio of length/width at the 90% level of all scattered points. RESULTS: By using the multiple regression analysis, we tested which HRV parameter (HR, SDNN, LF/HF, TI, or length/width) independently correlated with left ventricular ejection fraction (EF) or left ventricular diastolic dimension (EDD). The results demonstrated that TI and SDNN independently correlated with EF (multiple R = 0.59). Moreover, TI and SDNN independently correlated with EDD (multiple R = 0.45). CONCLUSION: TI and SDNN were indicators of the disease severity in myocardial dysfunction, while LF/HF, indicators of autonomic tone, did not have such an ability. It was of interest that the disease severity contributed to long-term fluctuations (TI, SDNN) of heart rate, rather than short-term fluctuations (LF/HF).
Osamu Minamihaba; Michiyasu Yamaki; Hitonobu Tomoike; Isao Kubota
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  8     ISSN:  1082-720X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-07-09     Completed Date:  2004-04-23     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-8     Citation Subset:  IM    
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
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MeSH Terms
Cardiomyopathy, Dilated / physiopathology*
Electrocardiography, Ambulatory
Heart Rate
Middle Aged
Myocardial Infarction / physiopathology*
Regression Analysis
Signal Processing, Computer-Assisted
Ventricular Function, Left

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