Document Detail

Severity of imported falciparum malaria: effect of taking antimalarial prophylaxis.
MedLine Citation:
PMID:  1422328     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effects of antimalarial chemoprophylaxis and other variables on the severity of falciparum malaria. DESIGN: Review of consecutive malaria cases between 1987 and 1991. SETTING: The Hospital for Tropical Diseases, London. SUBJECTS: 250 consecutive cases of mild and 51 consecutive cases of severe falciparum malaria. RESULTS: Prophylaxis was taken in 52.4% (131/250) of the cases of mild malaria and 21.6% (11/51) of cases of severe malaria. Severe malaria was more common in white patients than in those of African origin and was also seen more commonly in people returning from central, southern, and east Africa than in those returning from west Africa. Patients with severe malaria presented sooner than patients with mild malaria. CONCLUSIONS: Prior chemoprophylaxis led to a reduction in the severity of falciparum malaria. Ethnic origin, time to presentation, and sex were also associated with the severity of malaria.
S J Lewis; R N Davidson; E J Ross; A P Hall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  305     ISSN:  0959-8138     ISO Abbreviation:  BMJ     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-22     Completed Date:  1992-12-22     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  741-3     Citation Subset:  AIM; IM    
Hospital for Tropical Diseases, London.
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MeSH Terms
Africa / ethnology
Antimalarials / therapeutic use*
Malaria, Falciparum / ethnology,  pathology,  prevention & control*
Patient Compliance
Retrospective Studies
Sex Factors
Reg. No./Substance:
Comment In:
BMJ. 1992 Nov 28;305(6865):1364-5   [PMID:  1483093 ]
BMJ. 1992 Oct 17;305(6859):957   [PMID:  1458100 ]

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