Document Detail

Severity of episcleritis and systemic disease association.
MedLine Citation:
PMID:  10201593     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze patient characteristics and correlate between the site and severity of the inflammation and ocular and/or systemic disease association in a cohort of patients with episcleritis. DESIGN: Retrospective case series. METHODS: Medical records of 100 patients with episcleritis were reviewed. Data were analyzed using a customized database software. RESULTS: The age range at presentation was 18 to 76 years (mean, 43; median, 44). Sixty-nine percent of the patients were female. Thirty-two (32%) patients had bilateral involvement. The episcleritis was nodular in 23 eyes (16%). Half of the patients had a concurrent eye disease. Associated systemic disease was found in 36 patients (36%). In two patients, episcleritis preceded a systemic vasculitic disease (Wegener granulomatosis and Cogan syndrome). Ocular complications included uveitis (11.4%), corneal involvement (15%), and glaucoma (7.8%). No significant correlation of the site and severity of inflammation to the presence of associated systemic or ocular diseases was found. The mean follow-up was 16.5 months. Twenty-eight patients experienced recurrence of episcleritis during the follow-up. Half of the patients required treatment with oral nonsteroidal anti-inflammatory drugs. CONCLUSIONS: Episcleritis is usually a benign, self-limited disease, but it should not be trivialized since it may be associated with systemic disease and ocular complications. A careful review of systems should be performed in all patients presenting with episcleritis, and this should be repeated at least annually during the follow-up. A thorough eye examination is obviously essential to detect and treat ocular complications.
E K Akpek; H S Uy; W Christen; C Gurdal; C S Foster
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmology     Volume:  106     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-04-15     Completed Date:  1999-04-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  729-31     Citation Subset:  IM    
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Cohort Studies
Eye Diseases / complications
Glucocorticoids / therapeutic use
Middle Aged
Retrospective Studies
Scleritis / complications*,  drug therapy,  physiopathology
Severity of Illness Index
Vasculitis / complications*,  drug therapy,  physiopathology
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Glucocorticoids

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