Document Detail

Severity and duration of nausea and vomiting symptoms in pregnancy and spontaneous abortion.
MedLine Citation:
PMID:  20861299     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Earlier studies have shown an inverse association between the presence of nausea and vomiting in pregnancy (NVP) and spontaneous abortion (SAB), but no study to date has examined the effects of symptom duration on the risk of SAB.
METHODS: We examined NVP symptom severity and duration in relation to the occurrence of SAB. Data were collected from 2407 pregnant women in three US cities between 2000 and 2004 through interviews, ultrasound assessments and medical records abstractions. Discrete-time continuation ratio logistic survival models were used to examine the association between NVP and pregnancy loss.
RESULTS: Lack of NVP symptoms was associated with increased risk for SAB [adjusted odds ratio (OR) = 3.2, 95% confidence interval (CI): (2.4, 4.3)], compared with having any symptoms. Reduced risks for SAB were found across most maternal age groups for those with NVP for at least half of their pregnancy, but the effects were much stronger in the oldest maternal age group [OR = 0.2, 95% CI: (0.1, 0.8)].
CONCLUSIONS: The absence of NVP symptoms is associated with an increased risk of early pregnancy loss. As symptom duration decreases, the likelihood of early loss increases, especially among women in the oldest maternal age group.
Ronna L Chan; Andrew F Olshan; David A Savitz; Amy H Herring; Julie L Daniels; Herbert B Peterson; Sandra L Martin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-09-22
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  25     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-02-03     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2907-12     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous / etiology*
Logistic Models
Maternal Age
Nausea / complications*
Pregnancy Complications
Prospective Studies
Vomiting / complications*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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