| Severity of disease correlated with fever reduction in febrile infants. | |
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MedLine Citation:
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PMID: 2786183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective study of the effects of fever reduction on the clinical appearance of infants at risk for occult bacteremia was undertaken to study the hypothesis that infants with bacteremic illness fail to improve clinically following defervescence compared with infants with benign viral illness. A total of 154 children were enrolled in the study, including 19 with bacteremia: 13 with occult Streptococcus pneumoniae bacteremia, two with occult Haemophilus influenzae, type b bacteremia, and four with Haemophilus meningitis and bacteremia. There were no differences in degree of temperature reduction with acetaminophen between the bacteremic and nonbacteremic groups of infants. Among infants with bacteremia but without meningitis, differences from nonbacteremic children were detected in clinical appearance prior to fever reduction but not following defervescence. All patients with meningitis appeared seriously ill before and after defervescence. It was concluded that clinical improvement with defervescence is not a reliable indicator of the presence of occult bacteremia. Lack of clinical improvement with defervescence may be a reliable indicator for the presence of meningitis. Because there were differences in clinical appearance prior to fever reduction, routine administration of acetaminophen may interfere with the clinical evaluation by the physician. |
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Authors:
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R C Baker; T Tiller; J C Bausher; P S Bellet; W H Cotton; A H Finley; A M Lenane; C McHenry; K K Perez; R A Shapiro |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pediatrics Volume: 83 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-07-06 Completed Date: 1989-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1016-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Ambulatory and Community Pediatrics, Children's Hospital Medical Center, Cincinnati, OH 45229-2899. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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administration & dosage Body Temperature / drug effects Fever / diagnosis*, drug therapy Haemophilus Infections / diagnosis Haemophilus influenzae Humans Infant Meningitis, Haemophilus / diagnosis Meningitis, Pneumococcal / diagnosis Pneumococcal Infections / diagnosis Prognosis Prospective Studies Risk Factors Sepsis / diagnosis Virus Diseases / diagnosis |
| Chemical | |
Reg. No./Substance:
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103-90-2/Acetaminophen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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