Document Detail


Severity of abnormality influences decision to terminate pregnancies affected with fetal neural tube defects.
MedLine Citation:
PMID:  7524525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined parental decision concerning pregnancy management in women having fetuses with neural tube defects (NTDs) to determine whether severity of defect or method of detection has an impact on the decision making process. Analysis of decisions by 50 women, whose pregnancies were affected by an isolated neural tube defect (NTD) and characterized by a singleton gestation at 24 gestational weeks or less with normal chromosomal complement (46,XX or 46,XY), were assessed. All 23 women carrying fetuses with anencephaly elected to terminate their pregnancies. Of the 27 women carrying fetuses with spina bifida, 21 (77.8%) elected to terminate their pregnancies and 6 (22.2%) elected to continue their pregnancies. Of the 6 pregnancies that were continued, 4 were initially detected by ultrasonography and 2 were ascertained by maternal serum alpha-fetoprotein screening; defects ranged from 2 to 14 vertebral bodies, and none of the defects were craniad to the T9 level. This is in comparison to 5 of the 21 spina bifida cases that were elective pregnancy terminations, which were characterized by fetal lesions craniad to the T9 level. Severity of NTD thus appears to influence the decision to continue or terminate an affected pregnancy.
Authors:
C Grevengood; L P Shulman; J S Dungan; P Martens; O P Phillips; D S Emerson; R E Felker; J L Simpson; S Elias
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  9     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    1994 Jul-Aug
Date Detail:
Created Date:  1994-12-08     Completed Date:  1994-12-08     Revised Date:  2004-11-18    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  E; IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103-2896.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Induced*
Amniotic Fluid / chemistry
Female
Gestational Age
Humans
Karyotyping
Neural Tube Defects* / diagnosis,  pathology,  ultrasonography
Pregnancy
Pregnant Women*
alpha-Fetoproteins / analysis
Chemical
Reg. No./Substance:
0/alpha-Fetoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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