| Severity of abnormality influences decision to terminate pregnancies affected with fetal neural tube defects. | |
| | |
MedLine Citation:
|
PMID: 7524525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We examined parental decision concerning pregnancy management in women having fetuses with neural tube defects (NTDs) to determine whether severity of defect or method of detection has an impact on the decision making process. Analysis of decisions by 50 women, whose pregnancies were affected by an isolated neural tube defect (NTD) and characterized by a singleton gestation at 24 gestational weeks or less with normal chromosomal complement (46,XX or 46,XY), were assessed. All 23 women carrying fetuses with anencephaly elected to terminate their pregnancies. Of the 27 women carrying fetuses with spina bifida, 21 (77.8%) elected to terminate their pregnancies and 6 (22.2%) elected to continue their pregnancies. Of the 6 pregnancies that were continued, 4 were initially detected by ultrasonography and 2 were ascertained by maternal serum alpha-fetoprotein screening; defects ranged from 2 to 14 vertebral bodies, and none of the defects were craniad to the T9 level. This is in comparison to 5 of the 21 spina bifida cases that were elective pregnancy terminations, which were characterized by fetal lesions craniad to the T9 level. Severity of NTD thus appears to influence the decision to continue or terminate an affected pregnancy. |
| | |
Authors:
|
C Grevengood; L P Shulman; J S Dungan; P Martens; O P Phillips; D S Emerson; R E Felker; J L Simpson; S Elias |
Related Documents
:
|
6161585 - Separation of two pregnancy-associated proteins with sp1 determinants and the conversio... 906455 - Antituberculous therapy in pregnancy. risks to the fetus. 8883755 - Prolonged induction to delivery time in termination of pregnancy using 16, 16-dimethyl-... 2416925 - Should women at high risk of neural tube defect have an amniocentesis? 825795 - A study of complications in preterm deliveries after prolonged premature rupture of the... 1968025 - The clinical utility of the roll-over test in predicting pregnancy-induced hypertension... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Fetal diagnosis and therapy Volume: 9 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 1994 Jul-Aug |
Date Detail:
|
Created Date: 1994-12-08 Completed Date: 1994-12-08 Revised Date: 2004-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 273-7 Citation Subset: E; IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103-2896. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Induced* Amniotic Fluid / chemistry Female Gestational Age Humans Karyotyping Neural Tube Defects* / diagnosis, pathology, ultrasonography Pregnancy Pregnant Women* alpha-Fetoproteins / analysis |
| Chemical | |
Reg. No./Substance:
|
0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [Analysis of membrane expression of the CD63 human basophil activation marker. Applications to aller...
Next Document: Appearance of the myofibroblastic phenotype in Dupuytren's disease is associated with a fibronectin,...