| The severity of acute puumala hantavirus infection does not predict the long-term outcome of patients. | |
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MedLine Citation:
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PMID: 20502044 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: We have found greater urinary protein excretion and higher glomerular filtration rate (GFR) and blood pressure in patients 6 years after acute nephropathia epidemica (NE) compared with seronegative controls. The present aim was to establish whether the long-term outcome is determined by the severity of acute illness. METHODS: Serial plasma interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), creatinine, C-reactive protein, blood cell count as well as 24-hour urinary protein and overnight α(1)-microglobulin and albumin excretions were measured in 37 patients with acute NE. Human leucocyte antigen (HLA)-B, HLA-DRB1, TNF-α(-308) and IL-6(-174) alleles were also analyzed. After 6 years, GFR, blood pressure and urinary protein excretion were examined. RESULTS: There were no associations between the clinical severity of acute NE or the genetic factors determined and the increased GFR, hypertension or 24-hour urinary protein excretion observed 6 years later. The degree of inflammation during the acute phase was higher in patients who had increased urinary excretion of α(1)-microglobulin 6 years later compared with those with no α(1)-microglobulin excretion. CONCLUSION: Neither the severity of acute NE nor the host genetic factors determined the predicted renal function, blood pressure or 24-hour urinary protein excretion 6 years later. |
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Authors:
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Marja H Miettinen; Satu M Mäkelä; Ilpo O Ala-Houhala; Heini S A Huhtala; Mikko A Hurme; Tiit Kööbi; Jukka A Partanen; Amos I Pasternack; Antti Vaheri; Ilkka H Pörsti; Jukka T Mustonen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-21 |
Journal Detail:
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Title: Nephron. Clinical practice Volume: 116 ISSN: 1660-2110 ISO Abbreviation: Nephron Clin Pract Publication Date: 2010 |
Date Detail:
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Created Date: 2010-09-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101159763 Medline TA: Nephron Clin Pract Country: Switzerland |
Other Details:
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Languages: eng Pagination: c89-94 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Internal Medicine, Central Hospital of Jyväskylä, Jyväskylä, Finland. marja.miettinen@ksshp.fi |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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