| Severely modified lipoprotein properties without a change in cholesteryl ester transfer protein activity in patients with acute renal failure secondary to Hantaan virus infection. | |
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MedLine Citation:
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PMID: 20797315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with hemorrhagic fever with renal syndrome (HFRS) often exhibit altered serum lipid and lipoprotein profile during the oliguric phase of the disease. Serum lipid and lipoprotein profiles were assessed during the oliguric and recovery phases in six male patients with HFRS. In the oliguric phase of HFRS, the apolipoprotein (apo) C-III content in high-density lipoproteins (HDL) was elevated, whereas the apoA-I content was lowered. The level of expression and activity of antioxidant enzymes were severely reduced during the oliguric phase, while the cholesteryl ester transfer protein activity and protein level were unchanged between the phases. In the oliguric phase, electromobility of HDL2 and HDL3 was faster than in the recovery phase. Low-density lipoprotein (LDL) particle size was smaller and the distribution was less homogeneous. Patients with HFRS in the oliguric phase had severely modified lipoproteins in composition and metabolism. |
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Authors:
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Jihoe Kim; Hyun-Ho Park; Inho Choi; Young Ok Kim; Kyung-Hyun Cho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: BMB reports Volume: 43 ISSN: 1976-670X ISO Abbreviation: BMB Rep Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2010-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101465334 Medline TA: BMB Rep Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 535-40 Citation Subset: IM |
Affiliation:
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School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Kidney Injury
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blood,
etiology* Adult Apolipoprotein C-III / blood Cholesterol Ester Transfer Proteins / metabolism Hantaan virus* Hemorrhagic Fever with Renal Syndrome / blood*, complications Humans Lipids / blood Lipoproteins / blood*, chemistry* Lipoproteins, HDL2 / blood, chemistry Lipoproteins, HDL3 / blood, chemistry Lipoproteins, LDL / blood, chemistry Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein C-III; 0/Cholesterol Ester Transfer Proteins; 0/Lipids; 0/Lipoproteins; 0/Lipoproteins, HDL2; 0/Lipoproteins, HDL3; 0/Lipoproteins, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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