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Severe vitamin D deficiency is associated with nontuberculous mycobacterial lung disease: a case-control study.
MedLine Citation:
PMID:  23627546     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Previous studies have found evidence of an association between tuberculosis and vitamin D deficiency (VDD). However, the association between VDD and infection caused by nontuberculous mycobacteria (NTM) has never been studied. This study evaluated the prevalence and severity of VDD in NTM lung disease, and attempted to identify predictive factors. METHODS: Age- and sex-matched case-control study was conducted to assess the prevalence and severity of VDD in patients with NTM lung disease. RESULTS: After adjusting for potential confounding factors, the adjusted mean serum level of 25-hydroxyvitamin D [25(OH)D] levels was lower in 104 patients with NTM lung disease (10.7 ng/mL, 95% confidence interval [CI] 4.5-16.8 ng/mL) than that of 312 controls (13.7 ng/mL, 95% CI 7.4-19.5 ng/mL) (P = 0.012). Although the prevalence of VDD defined as serum 25(OH)D level <20 ng/ml was not different, severe VDD defined as serum 25(OH)D level <10 ng/ml was more prevalent in patients (P < 0.001). In multivariate analysis, severe (but not mild) VDD was independently associated with NTM lung disease (adjusted OR 3.9, 95% CI 1.9-8.5, P < 0.001). CONCLUSIONS: Patients with NTM lung disease have a high prevalence of severe VDD and VDD was independently associated with NTM lung disease. Further studies are needed to examine causality.
Authors:
Kyeongman Jeon; Su-Young Kim; Byeong-Ho Jeong; Boksoon Chang; Sung Jae Shin; Won-Jung Koh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-30
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Affiliation:
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine.
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