Document Detail

Severe valproic acid intoxication is associated with atrial tachycardia: secondary detoxication by hemoperfusion.
MedLine Citation:
PMID:  15770579     Owner:  NLM     Status:  MEDLINE    
Valproic acid is an anticonvulsant drug which is associated with serious toxicity including fatal outcome in case of severe intoxication. Secondary detoxication by hemodialysis or hemoperfusion has been employed successfully in valproic acid intoxication. Cardiac arrhythmias have only been described rarely in valproic acid intoxication in humans. We report on a 15 year-old boy with severe valproic acid intoxication (valproic acid plasma level on admission: 1 150 mg/l) who presented with coma, hypernatremia and atrial tachycardia. The patient was successfully treated with hemoperfusion and intensive supportive care without implementation of a specific antiarrhythmic therapy. We conclude that patients with severe valproic acid intoxication may benefit from secondary detoxication. In addition to generally known symptoms valproic acid intoxication may also be associated with cardiac arrhythmias.
S Meyer; M K Kuhlmann; F T Peters; H G Limbach; A Lindinger
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Klinische Pädiatrie     Volume:  217     ISSN:  0300-8630     ISO Abbreviation:  Klin Padiatr     Publication Date:    2005 Mar-Apr
Date Detail:
Created Date:  2005-03-16     Completed Date:  2005-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  82-5     Citation Subset:  IM    
Department of Pediatrics/Pediatric Intensive Care, University Hospital of the Saarland, Homburg/Saar, Germany.
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MeSH Terms
Ammonia / blood
Anticonvulsants / administration & dosage,  pharmacokinetics,  poisoning*
Atrial Fibrillation / blood,  chemically induced*,  diagnosis,  therapy
Coma / blood,  chemically induced,  therapy
Intensive Care*
Overdose / blood,  diagnosis,  therapy*
Suicide, Attempted
Valproic Acid / administration & dosage,  pharmacokinetics,  poisoning*
Reg. No./Substance:
0/Anticonvulsants; 7664-41-7/Ammonia; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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