Document Detail

Severe umbilical cord inflammation-a predictor of periventricular leukomalacia in very low birth weight infants.
MedLine Citation:
PMID:  15113634     Owner:  NLM     Status:  MEDLINE    
Chorioamnionitis has been associated with periventricular leukomalacia (PVL) in very low birth weight (VLBW) infants. We examined the association between the pathological severity of chorioamnionitis and PVL in VLBW infants. Thirty-four VLBW infants with PVL and 34 control infants matched for gestational age without a diagnosis of PVL or intraventricular hemorrhage were obtained from the Women and Infants' Hospital of Rhode Island's Neonatal Follow-up Clinic database. Placental samples, including the amnion/chorion, chorionic plate, and umbilical cord, were examined microscopically. Statistical analysis included Mantel-Haenszel chi-square, and Student's t-test. Severe inflammation in the umbilical cord was observed in 53% of infants with PVL and 32% without PVL (p<0.05). Severe umbilical cord inflammation is one of the risk factors associated with the development of PVL in VLBW infants.
Karen N Wharton; Halit Pinar; Barbara S Stonestreet; Richard Tucker; Kathryn R McLean; Michael Wallach; Betty R Vohr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  77     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-28     Completed Date:  2004-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  77-87     Citation Subset:  IM    
Department of Pediatrics, Women and Infants' Hospital of Rhode Island/Brown Medical School, Providence, RI 02905, USA.
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MeSH Terms
Case-Control Studies
Chorioamnionitis / complications,  pathology*
Infant, Newborn
Infant, Very Low Birth Weight*
Leukomalacia, Periventricular / etiology*
Logistic Models
Placenta / pathology
Retrospective Studies
Risk Factors
Umbilical Cord / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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