| Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment. | |
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MedLine Citation:
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PMID: 9565807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood. |
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Authors:
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P Scalfaro; J J Chesaux; P A Buchwalder; J Biollaz; J L Micheli |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Intensive care medicine Volume: 24 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-06-23 Completed Date: 1998-06-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 247-50 Citation Subset: IM; X |
Affiliation:
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Division of Neonatology, University Hospital, Lausanne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Lactic
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chemically induced*,
metabolism Adolescent Anti-HIV Agents / adverse effects*, pharmacokinetics Female HIV Seropositivity / transmission* Humans Infant, Newborn Infectious Disease Transmission, Vertical / prevention & control* Metabolic Clearance Rate Pregnancy Pregnancy Complications, Infectious* Zidovudine / adverse effects*, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 30516-87-1/Zidovudine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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