Document Detail


Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.
MedLine Citation:
PMID:  9565807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
Authors:
P Scalfaro; J J Chesaux; P A Buchwalder; J Biollaz; J L Micheli
Related Documents :
12197027 - Microvascularization of the mucocutaneous junction of the eyelid in fetuses and neonates.
17482897 - Peruvian contributions to the study on human reproduction at high altitude: from the ch...
19167577 - Disorders of the fetomaternal unit: hematologic manifestations in the fetus and neonate.
8922567 - Increased macrophage-colony stimulating factor levels in neonates with perinatal compli...
16797467 - Prediction of plasmodium falciparum placental infection according to the time of infect...
6738947 - Maternal and fetal factors in breech presentation.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  24     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-06-23     Completed Date:  1998-06-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  IM; X    
Affiliation:
Division of Neonatology, University Hospital, Lausanne, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acidosis, Lactic / chemically induced*,  metabolism
Adolescent
Anti-HIV Agents / adverse effects*,  pharmacokinetics
Female
HIV Seropositivity / transmission*
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Metabolic Clearance Rate
Pregnancy
Pregnancy Complications, Infectious*
Zidovudine / adverse effects*,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 30516-87-1/Zidovudine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pulse oximetry for assessment of pulsus paradoxus: a clinical study in children.
Next Document:  Heart transplantation without informed consent: discussion of a case.