Document Detail

Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.
MedLine Citation:
PMID:  9565807     Owner:  NLM     Status:  MEDLINE    
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
P Scalfaro; J J Chesaux; P A Buchwalder; J Biollaz; J L Micheli
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  24     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-06-23     Completed Date:  1998-06-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  IM; X    
Division of Neonatology, University Hospital, Lausanne, Switzerland.
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MeSH Terms
Acidosis, Lactic / chemically induced*,  metabolism
Anti-HIV Agents / adverse effects*,  pharmacokinetics
HIV Seropositivity / transmission*
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Metabolic Clearance Rate
Pregnancy Complications, Infectious*
Zidovudine / adverse effects*,  pharmacokinetics
Reg. No./Substance:
0/Anti-HIV Agents; 30516-87-1/Zidovudine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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