Document Detail

Severe transient hypertension after greater palatine foramen block in a patient taking midodrine.
MedLine Citation:
PMID:  19944906     Owner:  NLM     Status:  MEDLINE    
We report an episode of transient, severe hypertension occurring within 2 minutes of injection of 1% lidocaine with 1:100,000 U of epinephrine in a patient taking midodrine for orthostatic hypotension. We hypothesize that the patient's autonomic nervous system was dangerously susceptible to the effect of local anesthetic when combined with the vasoactive systemic effect of midodrine. Surgeons should minimize the use of vasoconstrictors in patients treated with midodrine to avoid hypertensive complications.
Mark D Rizzi; Robert J Weil; Robert R Lorenz
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-04-23
Journal Detail:
Title:  American journal of otolaryngology     Volume:  31     ISSN:  1532-818X     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-02-25     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-9     Citation Subset:  IM    
Children's Hospital of Philadelphia, Philadelphia, PA, USA.
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MeSH Terms
Anesthesia, Local / adverse effects*
Anesthetics, Local / adverse effects*
Epinephrine / adverse effects
Hypertension / chemically induced*
Lidocaine / adverse effects*
Middle Aged
Midodrine / adverse effects*
Palatine Tonsil
Vasoconstrictor Agents / adverse effects*
Reg. No./Substance:
0/Anesthetics, Local; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 42794-76-3/Midodrine; 51-43-4/Epinephrine
Comment In:
Am J Otolaryngol. 2011 Nov;32(6):634-5; author reply 635-6   [PMID:  21306789 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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