Document Detail

Severe toxic hepatitis associated with amoxycillin and clavulanic acid.
MedLine Citation:
PMID:  11422607     Owner:  NLM     Status:  MEDLINE    
Toxic hepatitis secondary to amoxycillin-clavulanic acid is an infrequent clinical picture. Most of the cases are reported to have a benign course. We report two cases of severe hepatic failure following amoxycillin-clavulanic acid use. One of the cases had cholestatic features primarily, and the other had hepatocellular injury prominently. The first case had also findings of trombotic trombositic purpura and had a fatal course.
G Ersoz; Z Karasu; C Yildiz; U S Akarca; G Yuce; Y Batur
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  26     ISSN:  0269-4727     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-25     Completed Date:  2001-08-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-9     Citation Subset:  IM    
Department of Gastroenterology, Ege University Medical School, Bornova, 35100 Izmir, Turkey.
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MeSH Terms
Amoxicillin-Potassium Clavulanate Combination / adverse effects*
Cholestasis / chemically induced
Drug Therapy, Combination / adverse effects*
Drug-Induced Liver Injury / etiology*
Fatal Outcome
Jaundice / chemically induced
Reg. No./Substance:
74469-00-4/Amoxicillin-Potassium Clavulanate Combination

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