| Severe thrombocytopenia following intraarterial papaverine administration for treatment of vasospasm. | |
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MedLine Citation:
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PMID: 7666219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Selective intraarterial infusion of papaverine is used in the treatment of symptomatic cerebral vasospasm. The authors report two episodes of severe thrombocytopenia in a patient that were related to intraarterial administration of papaverine. A 70-year-old man with a right internal carotid artery aneurysm underwent craniotomy and aneurysm clipping. He became lethargic 8 days after the hemorrhage occurred. Cerebral angiography revealed moderate vasospasm. In addition to hypervolemic-hypertensive therapy, the patient was treated on two occasions with intraarterial administration of papaverine. Within 24 hours of both treatments he developed severe thrombocytopenia. On one occasion epistaxis requiring transfusion of blood products occurred. Laboratory data support the diagnosis of immune-mediated papaverine-induced thrombocytopenia. The authors conclude that intraarterial administration of papaverine for treatment of vasospasm can be associated with severe, rapidly reversible thrombocytopenia. |
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Authors:
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J A Miller; D T Cross; C J Moran; R G Dacey; J G McFarland; M N Diringer |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurosurgery Volume: 83 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1995-10-12 Completed Date: 1995-10-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 435-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies / analysis Blood Platelets / immunology Cerebral Angiography Humans Infusions, Intra-Arterial Intracranial Aneurysm / complications, surgery Ischemic Attack, Transient / drug therapy*, etiology Male Papaverine / adverse effects* Subarachnoid Hemorrhage / complications, surgery Thrombocytopenia / chemically induced*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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