Document Detail

Severe thrombocytopenia following intraarterial papaverine administration for treatment of vasospasm.
MedLine Citation:
PMID:  7666219     Owner:  NLM     Status:  MEDLINE    
Selective intraarterial infusion of papaverine is used in the treatment of symptomatic cerebral vasospasm. The authors report two episodes of severe thrombocytopenia in a patient that were related to intraarterial administration of papaverine. A 70-year-old man with a right internal carotid artery aneurysm underwent craniotomy and aneurysm clipping. He became lethargic 8 days after the hemorrhage occurred. Cerebral angiography revealed moderate vasospasm. In addition to hypervolemic-hypertensive therapy, the patient was treated on two occasions with intraarterial administration of papaverine. Within 24 hours of both treatments he developed severe thrombocytopenia. On one occasion epistaxis requiring transfusion of blood products occurred. Laboratory data support the diagnosis of immune-mediated papaverine-induced thrombocytopenia. The authors conclude that intraarterial administration of papaverine for treatment of vasospasm can be associated with severe, rapidly reversible thrombocytopenia.
J A Miller; D T Cross; C J Moran; R G Dacey; J G McFarland; M N Diringer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  83     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-12     Completed Date:  1995-10-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-7     Citation Subset:  AIM; IM    
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
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MeSH Terms
Antibodies / analysis
Blood Platelets / immunology
Cerebral Angiography
Infusions, Intra-Arterial
Intracranial Aneurysm / complications,  surgery
Ischemic Attack, Transient / drug therapy*,  etiology
Papaverine / adverse effects*
Subarachnoid Hemorrhage / complications,  surgery
Thrombocytopenia / chemically induced*,  immunology
Reg. No./Substance:
0/Antibodies; 58-74-2/Papaverine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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