| Severe thoracic systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 6594114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of corticosteroid administration to eight patients with severe thoracic systemic lupus erythematosus (SLE) were assessed in a prospective study over a mean period of 26 months by serial measurements of respiratory function, ESR, and a clinical score. Initial assessment of respiratory function showed severe restrictive ventilatory defects and impairment of carbon monoxide uptake not wholly attributable to the small lung volumes. ESR and clinical score showed high correlation coefficients with FEV1 in all patients, with VC and TLC in seven patients, and with TLCO in four patients, indicating that changes of respiratory function were reflecting the activity of the disease. This study shows that in patients with severe thoracic SLE it is valid to use serial measurements of respiratory function to assess the response to treatment and that pronounced and sustained improvement of respiratory function can be expected. |
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Authors:
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C F McDonald; C E Barter; K J Fraser; J A Hanan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Australian and New Zealand journal of medicine Volume: 14 ISSN: 0004-8291 ISO Abbreviation: Aust N Z J Med Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-12-20 Completed Date: 1984-12-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1264322 Medline TA: Aust N Z J Med Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 239-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Azathioprine / therapeutic use Female Humans Lung Diseases / drug therapy, physiopathology* Lupus Erythematosus, Systemic / drug therapy, physiopathology* Middle Aged Prednisolone / therapeutic use Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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446-86-6/Azathioprine; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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