Document Detail

Severe thoracic systemic lupus erythematosus.
MedLine Citation:
PMID:  6594114     Owner:  NLM     Status:  MEDLINE    
The effects of corticosteroid administration to eight patients with severe thoracic systemic lupus erythematosus (SLE) were assessed in a prospective study over a mean period of 26 months by serial measurements of respiratory function, ESR, and a clinical score. Initial assessment of respiratory function showed severe restrictive ventilatory defects and impairment of carbon monoxide uptake not wholly attributable to the small lung volumes. ESR and clinical score showed high correlation coefficients with FEV1 in all patients, with VC and TLC in seven patients, and with TLCO in four patients, indicating that changes of respiratory function were reflecting the activity of the disease. This study shows that in patients with severe thoracic SLE it is valid to use serial measurements of respiratory function to assess the response to treatment and that pronounced and sustained improvement of respiratory function can be expected.
C F McDonald; C E Barter; K J Fraser; J A Hanan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian and New Zealand journal of medicine     Volume:  14     ISSN:  0004-8291     ISO Abbreviation:  Aust N Z J Med     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-12-20     Completed Date:  1984-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1264322     Medline TA:  Aust N Z J Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
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MeSH Terms
Azathioprine / therapeutic use
Lung Diseases / drug therapy,  physiopathology*
Lupus Erythematosus, Systemic / drug therapy,  physiopathology*
Middle Aged
Prednisolone / therapeutic use
Respiratory Function Tests
Reg. No./Substance:
446-86-6/Azathioprine; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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