| Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis. | |
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MedLine Citation:
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PMID: 16511396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines. Symptoms resolved when systemic corticosteroids were administered. This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis. |
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Authors:
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Rima McLeod; Asif Rashid Khan; Gwendolyn A Noble; Paul Latkany; Jessica Jalbrzikowski; Kenneth Boyer; |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 25 ISSN: 0891-3668 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-02 Completed Date: 2006-05-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: United States |
Other Details:
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Languages: eng Pagination: 270-2 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, The University of Chicago, Chicago, IL 60637, USA. rmcleod@midway.uchicago.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiprotozoal Agents / administration & dosage, adverse effects*, therapeutic use Child Chorioretinitis / congenital*, drug therapy, parasitology Drug Hypersensitivity / etiology, physiopathology* Drug Therapy, Combination Eosinophilia / etiology Female Humans Pyrimethamine / administration & dosage, therapeutic use Recurrence Severity of Illness Index Sulfadiazine / administration & dosage, adverse effects*, therapeutic use Toxoplasma / drug effects Toxoplasmosis, Ocular / congenital*, drug therapy, parasitology |
| Grant Support | |
ID/Acronym/Agency:
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AI 27530/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antiprotozoal Agents; 58-14-0/Pyrimethamine; 68-35-9/Sulfadiazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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