|Severe stroke: patient profile and predictors of favorable outcome.|
|PMID: 23140236 Owner: NLM Status: MEDLINE|
|BACKGROUND: Severe stroke carries high rates of mortality and morbidity. The aims of this study were to determine the characteristics of patients who initially presented with severe ischemic stroke, and to identify acute and subacute predictors of favorable clinical outcome in these patients.
METHODS: An observational cohort study, Acute Stroke Registry and Analysis of Lausanne (ASTRAL), was analyzed, and all patients presenting with severe stroke - defined as a National Institute of Health Stroke Scale score of ≥ 20 on admission - were compared with all other patients. In a multivariate analysis, associations with demographic, clinical, pathophysiologic, metabolic and neuroimaging factors were determined. Furthermore, we analyzed predictors of favorable outcome (modified Rankin scale score of ≤ 3 at 3 months) in the subgroup of severe stroke patients.
RESULTS: Of 1915 consecutive patients, 243 (12.7%) presented with severe stroke. This was significantly associated with cardio-embolic stroke mechanism (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.19-2.54), unknown stroke onset (OR 2.35, 95% CI 1.14-4.83), more neuroimaging signs of early ischemia (mostly computed tomography; OR 2.65, 95% CI 1.79-3.92), arterial occlusions on acute imaging (OR 27.01, 95% CI 11.5-62.9), fewer chronic radiologic infarcts (OR 0.43, 95% CI 0.26-0.72), lower hemoglobin concentration (OR 0.97, 95% CI 0.96-0.99), and higher white cell count (OR 1.05, 95% CI 1.00-1.11). In the 68 (28%) patients with favorable outcomes despite presenting with severe stroke, this was predicted by lower age (OR 0.94, 95% CI 0.92-0.97), preceding cerebrovascular events (OR 3.00, 95% CI 1.01-8.97), hypolipemic pretreatment (OR 3.82, 95% CI 1.34-10.90), lower acute temperature (OR 0.43, 95% CI 0.23-0.78), lower subacute glucose concentration (OR 0.74, 95% CI 0.56-0.97), and spontaneous or treatment-induced recanalization (OR 4.51, 95% CI 1.96-10.41).
CONCLUSIONS: Severe stroke presentation is predicted by multiple clinical, radiologic and metabolic variables, several of which are modifiable. Predictors in the 28% of patients with favorable outcome despite presenting with severe stroke include hypolipemic pretreatment, lower acute temperature, lower glucose levels at 24 h, and arterial recanalization.
|O Bill; P Zufferey; M Faouzi; P Michel|
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|Type: Journal Article|
|Title: Journal of thrombosis and haemostasis : JTH Volume: 11 ISSN: 1538-7836 ISO Abbreviation: J. Thromb. Haemost. Publication Date: 2013 Jan|
|Created Date: 2013-01-28 Completed Date: 2013-07-26 Revised Date: 2014-07-31|
Medline Journal Info:
|Nlm Unique ID: 101170508 Medline TA: J Thromb Haemost Country: England|
|Languages: eng Pagination: 92-9 Citation Subset: IM|
|© 2012 International Society on Thrombosis and Haemostasis.|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Biological Markers / blood
Blood Glucose / analysis
Hemoglobins / analysis
Hypolipidemic Agents / therapeutic use
Predictive Value of Tests
Severity of Illness Index
Stroke / blood, diagnosis*, etiology, mortality, physiopathology, therapy
Switzerland / epidemiology
|0/Biological Markers; 0/Blood Glucose; 0/Hemoglobins; 0/Hypolipidemic Agents|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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