| Severe sepsis and septic shock: review of the literature and emergency department management guidelines. | |
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MedLine Citation:
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PMID: 16781920 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma. Recent studies have led to a better understanding of the pathogenic mechanisms and the development of new or newly applied therapies. These therapies place early and aggressive management of severe sepsis and septic shock as integral to improving outcome. This independent review of the literature examines the recent pathogenic, diagnostic, and therapeutic advances in severe sepsis and septic shock for adults, with particular relevance to emergency practice. Recommendations are provided for therapies that have been shown to improve outcomes, including early goal-directed therapy, early and appropriate antimicrobials, source control, recombinant human activated protein C, corticosteroids, and low tidal volume mechanical ventilation. |
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Authors:
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H Bryant Nguyen; Emanuel P Rivers; Fredrick M Abrahamian; Gregory J Moran; Edward Abraham; Stephen Trzeciak; David T Huang; Tiffany Osborn; Dennis Stevens; David A Talan; |
Publication Detail:
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Type: Journal Article; Review Date: 2006-05-02 |
Journal Detail:
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Title: Annals of emergency medicine Volume: 48 ISSN: 1097-6760 ISO Abbreviation: Ann Emerg Med Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-19 Completed Date: 2006-06-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8002646 Medline TA: Ann Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 28-54 Citation Subset: AIM; IM |
Affiliation:
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Loma Linda University, Loma Linda, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Algorithms Anti-Bacterial Agents / therapeutic use* Cardiovascular Agents / therapeutic use Drug Therapy, Combination Humans Practice Guidelines as Topic Protein C / therapeutic use Recombinant Proteins / therapeutic use Respiration, Artificial Sepsis / diagnosis, epidemiology, etiology, therapy* Shock, Septic / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anti-Bacterial Agents; 0/Cardiovascular Agents; 0/Protein C; 0/Recombinant Proteins; 0/drotrecogin alfa activated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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