Document Detail

Severe recurrent hypoglycaemia following discontinuation of olanzapine.
MedLine Citation:
PMID:  21573263     Owner:  NLM     Status:  In-Data-Review    
Severe hypoglycaemia is a diagnostic challenge.1 It is often explained by mismatch between insulin doses, food ingestion and exercise. Recurrent hypoglycaemia can indicate underlying medical problems. Drug related events usually concern insulin or sulphonylureas. However, withdrawal of drugs which can cause insulin resistance can be causative if insulin or sulphonylureas continue.2We report the case of an insulin-treated patient who presented with severe recurrent hypoglycaemia. After exclusion of secondary causes of hypoglycaemia it was established that at the time of diagnosis of diabetes he had been taking olanzapine. This had subsequently been discontinued. Olanzapine is recognised to cause diabetes and diabetic ketoacidosis. Our patient was able to discontinue insulin therapy.
Sarah Steven; Rahul Nayar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acute medicine     Volume:  10     ISSN:  1747-4884     ISO Abbreviation:  Acute Med     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101553725     Medline TA:  Acute Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  32-4     Citation Subset:  IM    
MBChB BSc (Hons) MRCP (UK) Specialty Registrar in Diabetes and Endocrinology, Sunderland Royal Hospital, Sunderland.
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