Document Detail

Severe reaction to 5% imiquimod cream with excellent clinical and cosmetic outcomes.
MedLine Citation:
PMID:  17668546     Owner:  NLM     Status:  MEDLINE    
Imiquimod, an immune response modifier approved for the treatment of external genital warts, actinic keratoses, and superficial basal cell carcinoma, can induce a severe local inflammatory response. This phenomenon can accompany inappropriately overzealous, as well as entirely conventional, drug utilization. Despite strikingly brisk reactions, the 9 patients reported herein ultimately experienced excellent cosmetic and clinical outcomes. We report this series to alert clinicians of the good prognosis for a satisfactory outcome even when faced with extreme imiquimod cream-induced inflammation.
H L Greenberg; Joel L Cohen; Ted Rosen; Ida Orengo
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Publication Detail:
Type:  Case Reports    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  6     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-08-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  452-8     Citation Subset:  IM    
Division of Dermatology, Scott & White Memorial Hospital and Clinic,; Scott, Sherwood and Brindley Foundation, Texas A&M University System Health Science Center, College of Medicine, Temple, TX, USA.
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MeSH Terms
Adjuvants, Immunologic / administration & dosage,  adverse effects,  chemistry
Administration, Topical
Aged, 80 and over
Aminoquinolines / administration & dosage,  adverse effects*,  chemistry
Cheilitis / chemically induced,  drug therapy
Drug Eruptions / drug therapy,  etiology*
Keratosis / chemically induced,  drug therapy
Middle Aged
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Aminoquinolines; 0/Ointments; 99011-02-6/imiquimod

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