| Severe pulmonary hypertension without right ventricular failure: the unique hearts of patients with Eisenmenger syndrome. | |
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MedLine Citation:
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PMID: 11779519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Why adults with the Eisenmenger syndrome fare so much better than other patients with severe pulmonary hypertension is not known, but may be related to unique hemodynamics found only in these patients and in normal fetuses. We used echocardiography to evaluate ventricular morphology and function in 80 subjects: 45 cyanotic adults and 5 cyanotic adolescents with Eisenmenger syndrome, 10 infants with nonrestrictive ventricular septal defect and left-to-right shunt flow (pre-Eisenmenger phase), and 20 fetuses with structurally normal hearts. Cross-sectional morphology of the hearts was the same in all 4 groups with a flat ventricular septum throughout the cardiac cycle and equal thickness of the right and left ventricular free walls (regression slope 0.98, r = 0.97, p <0.0001). This morphology was the same in patients independent of age, defect type, and ventricular function. Right ventricular fractional area change was slightly inferior to that of the left ventricle but normal in most patients with Eisenmenger syndrome (0.47 +/- 0.14 vs 0.51 +/- 0.13, p <0.01). Overall, there was a highly significant linear relation between right and left ventricular function (r = 0.81, p <0.0001). The hearts of patients with Eisenmenger syndrome are more like normal fetal hearts than normal adult hearts. Because of the unique cardiovascular hemodynamics, regression of right ventricular wall thickness does not occur and is likely the reason that patients with Eisenmenger syndrome fare so much better than other adults with severe pulmonary hypertension. |
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Authors:
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William E Hopkins; Alan D Waggoner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 89 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-07 Completed Date: 2002-01-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 34-8 Citation Subset: AIM; IM |
Affiliation:
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Cardiology Unit, University of Vermont College of Medicine, Burlington, Vermont 05401, USA. hopkins@vtmednet.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Echocardiography, Doppler Eisenmenger Complex / complications, physiopathology*, ultrasonography Female Fetal Diseases / physiopathology Hemodynamics Humans Hypertension, Pulmonary / complications, physiopathology* Infant Infant, Newborn Male Middle Aged Pregnancy Ventricular Dysfunction, Right / physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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