Document Detail

Severe pulmonary hypertension in a neonate caused by premature closure of the ductus arteriosus following maternal treatment with diclofenac: a case report.
MedLine Citation:
PMID:  9773385     Owner:  NLM     Status:  MEDLINE    
The administration of non-steroidal antiinflammatory drugs (NSAID) has occasionally been related to fetal and neonatal cardiopulmonary, gastrointestinal, cerebral and renal complications. This report describes a term newborn with severe persistent pulmonary hypertension due to premature closure of the ductus arteriosus following a 5 day maternal treatment with diclofenac two weeks before delivery. Pulmonary hypertension only responded to unusually high doses of inhaled NO. The treatment was necessary for 22 days suggesting structural alteration of pulmonary vasculature. The child recovered, but tricuspid regurgitation persisted, presumably because of irreversible ischemic damage of one papillary muscle. This is the first reported case of persistent pulmonary hypertension of the newborn (PPHN) in association with maternal diclofenac treatment and represents a most severe form of PPHN induced by NSAID.
M Zenker; J Klinge; C Krüger; H Singer; J Scharf
Related Documents :
10028875 - A case of truncus arteriosus type ii.
18045295 - Hemodynamic features of congenital aortic valve stenosis with patent ductus arteriosus ...
20539495 - Patents.
6735015 - Echocardiographic features of truncal abnormalities. special emphasis to the evaluation...
7434215 - Renal fibromuscular hyperplasia associated with subarachnoid hemorrhage from a berry an...
23881175 - Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylargin...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  26     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-10     Completed Date:  1998-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  231-4     Citation Subset:  IM    
University Hospital for Children and Adolescents, Erlangen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Diclofenac / adverse effects*
Ductus Arteriosus / abnormalities*
Hypertension, Pulmonary / etiology*
Infant, Newborn
Maternal-Fetal Exchange*
Papillary Muscles / pathology
Tricuspid Valve Insufficiency / etiology
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 15307-86-5/Diclofenac

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fetal cerebral AV-malformation and cardiomegaly, diagnostic and therapeutic problems.
Next Document:  Intrauterine growth acceleration in the case of a severe form of mucopolysaccharidosis type VII.