Document Detail


Severe pulmonary hypertension in a neonate caused by premature closure of the ductus arteriosus following maternal treatment with diclofenac: a case report.
MedLine Citation:
PMID:  9773385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The administration of non-steroidal antiinflammatory drugs (NSAID) has occasionally been related to fetal and neonatal cardiopulmonary, gastrointestinal, cerebral and renal complications. This report describes a term newborn with severe persistent pulmonary hypertension due to premature closure of the ductus arteriosus following a 5 day maternal treatment with diclofenac two weeks before delivery. Pulmonary hypertension only responded to unusually high doses of inhaled NO. The treatment was necessary for 22 days suggesting structural alteration of pulmonary vasculature. The child recovered, but tricuspid regurgitation persisted, presumably because of irreversible ischemic damage of one papillary muscle. This is the first reported case of persistent pulmonary hypertension of the newborn (PPHN) in association with maternal diclofenac treatment and represents a most severe form of PPHN induced by NSAID.
Authors:
M Zenker; J Klinge; C Krüger; H Singer; J Scharf
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  26     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-10     Completed Date:  1998-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  231-4     Citation Subset:  IM    
Affiliation:
University Hospital for Children and Adolescents, Erlangen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Diclofenac / adverse effects*
Ductus Arteriosus / abnormalities*
Female
Humans
Hypertension, Pulmonary / etiology*
Infant, Newborn
Maternal-Fetal Exchange*
Necrosis
Papillary Muscles / pathology
Pregnancy
Tricuspid Valve Insufficiency / etiology
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 15307-86-5/Diclofenac

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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