Document Detail

Severe pulmonary hypertension in chronic idiopathic myelofibrosis.
MedLine Citation:
PMID:  15585978     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic myeloproliferative disorders (CMPD) seem to be associated with an increased risk for pulmonary hypertension (PH). CASE REPORT: A patient with history of chronic idiopathic myelofibrosis (CIMF) presented with progressive dyspnea (New York Heart Association class III). Until this time he had not received specific treatment for CIMF. Echocardiography and rightheart catheterization confirmed PH. Further diagnostic procedures excluded a specific cause of PH. Therefore, primary PH was assumed. 2 years later he presented again with progressive dyspnea due to a progress of PH. A few days later the patient died from acute posterior myocardial infarction. Pathologic examination of the lung showed an obstruction of the small vessels by conglomerates of megakaryocytes. DISCUSSION: We conclude that PH developed secondarily due to CMPD. PH should be suspected in patients with CMPD and should influence the decision for treatment of CMPD.
M Halank; C Marx; G Baretton; K-M Müller; G Ehninger; G Höffken
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Onkologie     Volume:  27     ISSN:  0378-584X     ISO Abbreviation:  Onkologie     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-12-08     Completed Date:  2005-01-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7808556     Medline TA:  Onkologie     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  472-4     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger GmbH, Freiburg.
Medizinische Klinik I, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Deutschland.
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MeSH Terms
Chronic Disease
Dyspnea / diagnosis*,  etiology*
Hypertension, Pulmonary / diagnosis*,  etiology*
Middle Aged
Physician's Practice Patterns
Primary Myelofibrosis / complications*,  diagnosis*
Severity of Illness Index

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