Document Detail

Severe pulmonary arterial hypertension in a very premature baby with bronchopulmonary dysplasia: normalization with long-term sildenafil.
MedLine Citation:
PMID:  19829144     Owner:  NLM     Status:  MEDLINE    
Bronchopulmonary dysplasia is a common adverse outcome of very premature babies treated with long-lasting ventilation and oxygen therapy. Infants with bronchopulmonary dysplasia may develop pulmonary arterial hypertension. We report on severe bronchopulmonary dysplasia in a preterm infant who developed secondary, symptomatic and progressively severe pulmonary arterial hypertension. He was treated with sildenafil for 12 months, with complete resolution of pulmonary arterial hypertension. Eighteen months after therapy discontinuation, the patient was asymptomatic, and his systolic pulmonary artery pressure was normal. Routine use of sildenafil in preterm infants with bronchopulmonary dysplasia and secondary pulmonary arterial hypertension could be the future; large studies should confirm this report.
Salvatore Caputo; Giuseppe Furcolo; Raffaello Rabuano; Angelo Maria Basilicata; Luigi Maria Pilla; Alfredo De Simone; Brigida Pasquariello; Quirino Ciampi; Gennaro Vetrano; Bruno Villari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  11     ISSN:  1558-2035     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  704-6     Citation Subset:  IM    
Division of Cardiology, Italy.
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MeSH Terms
Antihypertensive Agents / administration & dosage*
Blood Pressure / drug effects*
Bronchopulmonary Dysplasia / complications*,  physiopathology,  ultrasonography
Drug Administration Schedule
Gestational Age
Hypertension, Pulmonary / drug therapy*,  etiology,  physiopathology,  ultrasonography
Infant, Newborn
Infant, Premature*
Piperazines / administration & dosage*
Purines / administration & dosage
Severity of Illness Index
Sulfones / administration & dosage*
Time Factors
Treatment Outcome
Vasodilator Agents / administration & dosage*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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