| Severe pulmonary arterial hypertension in a very premature baby with bronchopulmonary dysplasia: normalization with long-term sildenafil. | |
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MedLine Citation:
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PMID: 19829144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bronchopulmonary dysplasia is a common adverse outcome of very premature babies treated with long-lasting ventilation and oxygen therapy. Infants with bronchopulmonary dysplasia may develop pulmonary arterial hypertension. We report on severe bronchopulmonary dysplasia in a preterm infant who developed secondary, symptomatic and progressively severe pulmonary arterial hypertension. He was treated with sildenafil for 12 months, with complete resolution of pulmonary arterial hypertension. Eighteen months after therapy discontinuation, the patient was asymptomatic, and his systolic pulmonary artery pressure was normal. Routine use of sildenafil in preterm infants with bronchopulmonary dysplasia and secondary pulmonary arterial hypertension could be the future; large studies should confirm this report. |
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Authors:
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Salvatore Caputo; Giuseppe Furcolo; Raffaello Rabuano; Angelo Maria Basilicata; Luigi Maria Pilla; Alfredo De Simone; Brigida Pasquariello; Quirino Ciampi; Gennaro Vetrano; Bruno Villari |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular medicine (Hagerstown, Md.) Volume: 11 ISSN: 1558-2035 ISO Abbreviation: J Cardiovasc Med (Hagerstown) Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101259752 Medline TA: J Cardiovasc Med (Hagerstown) Country: United States |
Other Details:
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Languages: eng Pagination: 704-6 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Italy. dr.caputo@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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administration & dosage* Blood Pressure / drug effects* Bronchopulmonary Dysplasia / complications*, physiopathology, ultrasonography Drug Administration Schedule Gestational Age Humans Hypertension, Pulmonary / drug therapy*, etiology, physiopathology, ultrasonography Infant, Newborn Infant, Premature* Male Piperazines / administration & dosage* Purines / administration & dosage Severity of Illness Index Sulfones / administration & dosage* Time Factors Treatment Outcome Vasodilator Agents / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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