Document Detail

Severe primary hyperparathyroidism in a neonate having a parent with hypercalcemia: treatment by total parathyroidectomy and simultaneous heterotopic autotransplantation.
MedLine Citation:
PMID:  2237775     Owner:  NLM     Status:  MEDLINE    
Neonatal primary hyperparathyroidism is a life-threatening disease because of marked hypercalcemia and severe respiratory distress caused by the hypoplastic thorax and occasional rib fractures. We report a 29-day-old girl treated by total parathyroidectomy and simultaneous autotransplantation of parathyroid tissue (one fifth of each of the two glands) in the femoral quadriceps muscle near the groin. At the time of operation, all four of the parathyroid glands were markedly enlarged, and their total weight was 900 mg. Part of the resected parathyroid tissue was cryopreserved for further autotransplantation should hypoparathyroidism develop. Two years six months after surgery, the infant was well and had normal levels of serum calcium and immunoreactive parathyroid hormone in the absence of any supplementary treatment. Asymptomatic hypercalcemia in the presence of abnormally low fractional excretion of calcium was found in the father. Based on our experience and review of the literature, we recommend total parathyroidectomy, autotransplantation, and cryopreservation for the neonate with primary hyperparathyroidism.
Y Fujimoto; H Hazama; K Oku
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Surgery     Volume:  108     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-04     Completed Date:  1990-12-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  933-8     Citation Subset:  AIM; IM    
Department of Endocrine Surgery, Tokyo Women's Medical College, Japan.
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MeSH Terms
Calcium / blood
Hypercalcemia / genetics
Hyperparathyroidism / blood,  genetics,  surgery*
Infant, Newborn
Parathyroid Glands / transplantation*
Transplantation, Heterotopic*
Reg. No./Substance:

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