| Severe primary hyperparathyroidism in a neonate having a parent with hypercalcemia: treatment by total parathyroidectomy and simultaneous heterotopic autotransplantation. | |
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MedLine Citation:
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PMID: 2237775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal primary hyperparathyroidism is a life-threatening disease because of marked hypercalcemia and severe respiratory distress caused by the hypoplastic thorax and occasional rib fractures. We report a 29-day-old girl treated by total parathyroidectomy and simultaneous autotransplantation of parathyroid tissue (one fifth of each of the two glands) in the femoral quadriceps muscle near the groin. At the time of operation, all four of the parathyroid glands were markedly enlarged, and their total weight was 900 mg. Part of the resected parathyroid tissue was cryopreserved for further autotransplantation should hypoparathyroidism develop. Two years six months after surgery, the infant was well and had normal levels of serum calcium and immunoreactive parathyroid hormone in the absence of any supplementary treatment. Asymptomatic hypercalcemia in the presence of abnormally low fractional excretion of calcium was found in the father. Based on our experience and review of the literature, we recommend total parathyroidectomy, autotransplantation, and cryopreservation for the neonate with primary hyperparathyroidism. |
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Authors:
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Y Fujimoto; H Hazama; K Oku |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Surgery Volume: 108 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1990-12-04 Completed Date: 1990-12-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 933-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Endocrine Surgery, Tokyo Women's Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calcium
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blood Female Groin Humans Hypercalcemia / genetics Hyperparathyroidism / blood, genetics, surgery* Infant, Newborn Parathyroid Glands / transplantation* Parathyroidectomy* Transplantation, Heterotopic* |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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