Document Detail


Severe pregnancy complication (preeclampsia) is associated with greater periodontal destruction.
MedLine Citation:
PMID:  15830648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Preeclampsia is a pregnancy-specific disease which is one of the leading causes of maternal and fetal morbidity and mortality. The etiology of preeclampsia remains elusive. The underlying pathology may be related to a generalized intravascular hyperinflammatory state. Since the placental histopathologic lesions of acute atherosis, seen in preeclampsia, bear resemblance to those seen in atherosclerosis, and recent evidence links atherosclerosis with chronic infection, we decided to investigate a possible link between preeclampsia and chronic periodontal infection. METHODS: Thirty primigravidas, 15 suffering from preeclampsia, had full mouth periodontal examinations. Gingival crevicular fluid samples were taken for laboratory immunological assessment. Similar examination and sampling were performed in 15 age- and maternal status-matched controls. RESULTS: Significantly higher periodontal probing depth and clinical attachment level scores were found in the preeclamptic group compared with controls (2.98 versus 2.11 and 3.33 versus 2.30, respectively). Plaque index, gingival index, and mean gingival overgrowth scores were very similar in both groups. Furthermore, prostaglandin E2 (PGE2), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta levels were all significantly higher in the preeclamptic group (247.4 ngr/sample versus 89.1 ngr/sample, 8.03 pgr/sample versus 4.03 pgr/sample, and 175.7 pgr/sample versus 62.2 pgr/sample, respectively). CONCLUSION: The above results suggest a possible association between periodontal inflammation and preeclampsia.
Authors:
Orit Oettinger-Barak; Shlomi Barak; Gonen Ohel; Moshe Oettinger; Harald Kreutzer; Micha Peled; Eli E Machtei
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of periodontology     Volume:  76     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-04-15     Completed Date:  2005-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-7     Citation Subset:  D; IM    
Affiliation:
Rambam Medical Center, Haifa, Israel. o_o-barak@rambam.health.gov.il
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MeSH Terms
Descriptor/Qualifier:
Dinoprostone / analysis
Female
Gingival Crevicular Fluid / chemistry,  immunology
Humans
Interleukin-1 / analysis
Periodontal Diseases / complications*,  immunology
Pre-Eclampsia / etiology*,  immunology
Pregnancy
Tumor Necrosis Factor-alpha / analysis
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/Tumor Necrosis Factor-alpha; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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