Document Detail

Severe preeclampsia in antithrombin III deficiency with no history of venous thromboembolism.
MedLine Citation:
PMID:  11506257     Owner:  NLM     Status:  MEDLINE    
Complications of pregnancy, such as preeclampsia, placental abruption, fetal growth retardation, still-birth and fetal death are associated with an increased frequency of pro-thrombotic abnormalities. We describe a case of severe preeclampsia and multiple placental infarctions in a 28-year-old woman at 31 weeks' gestation. Despite a negative personal history for venous thromboembolism, coagulation screening for thrombophilia detected an isolated antithrombin III deficiency. In view of the high prevalence of pro-thrombotic complications, laboratory screening for thrombophilia would be advantageous in women with complicated pregnancies, to ensure adequate management in high-risk situations, as suggested by larger-scale clinical investigations.
L Gammaro; G Lippi; E Bottini; G Valenti; F Manzato; N Tessitore; G Maschio
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of nephrology     Volume:  14     ISSN:  1121-8428     ISO Abbreviation:  J. Nephrol.     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-08-16     Completed Date:  2002-08-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  312-5     Citation Subset:  IM    
Division of Nephrology, Verona Hospital, Italy.
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MeSH Terms
Antithrombin III Deficiency / complications*
Pre-Eclampsia / etiology*
Pregnancy Complications, Hematologic*
Severity of Illness Index

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